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The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration
Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Low-density lipoprotein receptor (LDLR) plays a critical role in plasma lipoprotein hemostasis, which is involved in the formation of atherosclerotic plaque. This study aimed to evaluate whether LDLR gene polymo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599626/ https://www.ncbi.nlm.nih.gov/pubmed/33003376 http://dx.doi.org/10.3390/biom10101381 |
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author | Vargas-Alarcon, Gilberto Perez-Mendez, Oscar Ramirez-Bello, Julian Posadas-Sanchez, Rosalinda Gonzalez-Pacheco, Hector Escobedo, Galileo Nieto-Lima, Betzabe Carreon-Torres, Elizabeth Fragoso, Jose Manuel |
author_facet | Vargas-Alarcon, Gilberto Perez-Mendez, Oscar Ramirez-Bello, Julian Posadas-Sanchez, Rosalinda Gonzalez-Pacheco, Hector Escobedo, Galileo Nieto-Lima, Betzabe Carreon-Torres, Elizabeth Fragoso, Jose Manuel |
author_sort | Vargas-Alarcon, Gilberto |
collection | PubMed |
description | Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Low-density lipoprotein receptor (LDLR) plays a critical role in plasma lipoprotein hemostasis, which is involved in the formation of atherosclerotic plaque. This study aimed to evaluate whether LDLR gene polymorphisms are significantly associated with ACS and the plasma lipids profile. Three LDLR gene polymorphisms located in the UTR′3 region (c.*52 A/G, c.*504 A/G, and c.* 773 A/G) were determined using TaqMan genotyping assays in a group of 618 ACS patients and 666 healthy controls. Plasma lipids profile concentrations were determined by enzymatic/colorimetric assays. Under co-dominant and recessive models, the c.*52 A allele of the c.*52 A/G polymorphism was associated with a higher risk of ACS (OR = 2.02, pC(Co-dom) = 0.033, and OR = 2.00, pC(Res) = 0.009, respectively). In the same way, under co-dominant and recessive models, the c.*773 G allele of the c.*773 A/G polymorphism was associated with a high risk of ACS (OR = 2.04, pC(Co-dom) = 0.027, and OR = 2.01, pC(Res) = 0.007, respectively). The “AAG” haplotype was associated with a high risk of ACS (OR = 1.22, pC = 0.016). The c.*52 AA genotype showed a lower HDL-C concentration than individuals with the GG genotype. In addition, carriers of c.*773 GG genotype carriers had a lower concentration of the high-density lipoprotein-cholesterol (HDL-C) than subjects with the AA genotype. Our data suggest the association of the LDLR c.*773 A/G and LDLR c.*52 A/G polymorphisms with both the risk of developing ACS and with a lower concentration of HDL-C in the study population. |
format | Online Article Text |
id | pubmed-7599626 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75996262020-11-01 The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration Vargas-Alarcon, Gilberto Perez-Mendez, Oscar Ramirez-Bello, Julian Posadas-Sanchez, Rosalinda Gonzalez-Pacheco, Hector Escobedo, Galileo Nieto-Lima, Betzabe Carreon-Torres, Elizabeth Fragoso, Jose Manuel Biomolecules Article Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Low-density lipoprotein receptor (LDLR) plays a critical role in plasma lipoprotein hemostasis, which is involved in the formation of atherosclerotic plaque. This study aimed to evaluate whether LDLR gene polymorphisms are significantly associated with ACS and the plasma lipids profile. Three LDLR gene polymorphisms located in the UTR′3 region (c.*52 A/G, c.*504 A/G, and c.* 773 A/G) were determined using TaqMan genotyping assays in a group of 618 ACS patients and 666 healthy controls. Plasma lipids profile concentrations were determined by enzymatic/colorimetric assays. Under co-dominant and recessive models, the c.*52 A allele of the c.*52 A/G polymorphism was associated with a higher risk of ACS (OR = 2.02, pC(Co-dom) = 0.033, and OR = 2.00, pC(Res) = 0.009, respectively). In the same way, under co-dominant and recessive models, the c.*773 G allele of the c.*773 A/G polymorphism was associated with a high risk of ACS (OR = 2.04, pC(Co-dom) = 0.027, and OR = 2.01, pC(Res) = 0.007, respectively). The “AAG” haplotype was associated with a high risk of ACS (OR = 1.22, pC = 0.016). The c.*52 AA genotype showed a lower HDL-C concentration than individuals with the GG genotype. In addition, carriers of c.*773 GG genotype carriers had a lower concentration of the high-density lipoprotein-cholesterol (HDL-C) than subjects with the AA genotype. Our data suggest the association of the LDLR c.*773 A/G and LDLR c.*52 A/G polymorphisms with both the risk of developing ACS and with a lower concentration of HDL-C in the study population. MDPI 2020-09-29 /pmc/articles/PMC7599626/ /pubmed/33003376 http://dx.doi.org/10.3390/biom10101381 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vargas-Alarcon, Gilberto Perez-Mendez, Oscar Ramirez-Bello, Julian Posadas-Sanchez, Rosalinda Gonzalez-Pacheco, Hector Escobedo, Galileo Nieto-Lima, Betzabe Carreon-Torres, Elizabeth Fragoso, Jose Manuel The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration |
title | The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration |
title_full | The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration |
title_fullStr | The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration |
title_full_unstemmed | The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration |
title_short | The c.*52 A/G and c.*773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration |
title_sort | c.*52 a/g and c.*773 a/g genetic variants in the utr′3 of the ldlr gene are associated with the risk of acute coronary syndrome and lower plasma hdl-cholesterol concentration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599626/ https://www.ncbi.nlm.nih.gov/pubmed/33003376 http://dx.doi.org/10.3390/biom10101381 |
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