Protective Effects of ALDH1A Enzyme Inhibition on Helicobacter-Induced Colitis in Smad3(−/−) Mice are Associated with Altered α4ß7 Integrin Expression on Activated T Cells

Many inflammatory bowel disease (IBD) patients require surgical intervention due to limited pharmacological treatment options. Antibodies targeting α4ß7, a gut-homing integrin, are one of the most promising IBD treatments. As retinoic acid (RA) regulates expression of gut-homing proteins including α...

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Detalles Bibliográficos
Autores principales: Seamons, Audrey, Haenisch, Michael, Meeker, Stacey, Pershutkina, Olesya, Brabb, Thea, Treuting, Piper M., Paik, Jisun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599670/
https://www.ncbi.nlm.nih.gov/pubmed/32987910
http://dx.doi.org/10.3390/nu12102927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599670/
https://www.ncbi.nlm.nih.gov/pubmed/32987910
http://dx.doi.org/10.3390/nu12102927

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