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Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry

(1) Introduction: The incidence of venous thromboembolisms (VTE) has not been extensively analyzed in patients with antineutrophil cytoplasmic antibody (ANCA)-glomerulonephritis (ANCA-GN). Thus, the aim of the present study was to assess the frequency and the risk factors of VTE in patients with ANC...

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Autores principales: Henry, Nicolas, Brilland, Benoit, Wacrenier, Samuel, Djema, Assia, Garnier, Anne Sophie, Gansey, Renaud, Coindre, Jean-Philippe, Besson, Virginie, Duveau, Agnès, Subra, Jean-François, Cousin, Maud, Piccoli, Giorgina Barbara, Augusto, Jean-François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599765/
https://www.ncbi.nlm.nih.gov/pubmed/33007967
http://dx.doi.org/10.3390/jcm9103177
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author Henry, Nicolas
Brilland, Benoit
Wacrenier, Samuel
Djema, Assia
Garnier, Anne Sophie
Gansey, Renaud
Coindre, Jean-Philippe
Besson, Virginie
Duveau, Agnès
Subra, Jean-François
Cousin, Maud
Piccoli, Giorgina Barbara
Augusto, Jean-François
author_facet Henry, Nicolas
Brilland, Benoit
Wacrenier, Samuel
Djema, Assia
Garnier, Anne Sophie
Gansey, Renaud
Coindre, Jean-Philippe
Besson, Virginie
Duveau, Agnès
Subra, Jean-François
Cousin, Maud
Piccoli, Giorgina Barbara
Augusto, Jean-François
author_sort Henry, Nicolas
collection PubMed
description (1) Introduction: The incidence of venous thromboembolisms (VTE) has not been extensively analyzed in patients with antineutrophil cytoplasmic antibody (ANCA)-glomerulonephritis (ANCA-GN). Thus, the aim of the present study was to assess the frequency and the risk factors of VTE in patients with ANCA-GN. (2) Methods: Patients from the Maine-Anjou ANCA-associated vasculitis (AAV) registry with a biopsy showing pauci-immune glomerulonephritis were included. VTE events, site, and interval from AAV diagnosis were analyzed. (3) Results: 133 patients fulfilled the inclusion criteria of the study and were analyzed. VTE episodes were diagnosed in 23/133 (17.3%) patients at a median delay of 3 months from ANCA-GN diagnosis. Patients with VTE had lower serum albumin (p = 0.040), were less frequently on statin therapy (p = 0.009) and had less frequently proteinase-3 (PR3)-ANCAs (p = 0.078). Univariate analysis identified higher age (p = 0.022), lower serum albumin (p = 0.030), lack of statin therapy (p = 0.009), and rituximab treatment (p = 0.018) as significant risk factors of VTE. In multivariate analysis, only lack of statin therapy (HR 4.873; p = 0.042) was significantly associated with VTE. (4) Conclusion: Patients with ANCA-GN are at high risk of VTE, especially within the first months following AAV diagnosis. Our results suggest that statin therapy is associated with a lower risk of VTE in ANCA-GN patients.
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spelling pubmed-75997652020-11-01 Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry Henry, Nicolas Brilland, Benoit Wacrenier, Samuel Djema, Assia Garnier, Anne Sophie Gansey, Renaud Coindre, Jean-Philippe Besson, Virginie Duveau, Agnès Subra, Jean-François Cousin, Maud Piccoli, Giorgina Barbara Augusto, Jean-François J Clin Med Article (1) Introduction: The incidence of venous thromboembolisms (VTE) has not been extensively analyzed in patients with antineutrophil cytoplasmic antibody (ANCA)-glomerulonephritis (ANCA-GN). Thus, the aim of the present study was to assess the frequency and the risk factors of VTE in patients with ANCA-GN. (2) Methods: Patients from the Maine-Anjou ANCA-associated vasculitis (AAV) registry with a biopsy showing pauci-immune glomerulonephritis were included. VTE events, site, and interval from AAV diagnosis were analyzed. (3) Results: 133 patients fulfilled the inclusion criteria of the study and were analyzed. VTE episodes were diagnosed in 23/133 (17.3%) patients at a median delay of 3 months from ANCA-GN diagnosis. Patients with VTE had lower serum albumin (p = 0.040), were less frequently on statin therapy (p = 0.009) and had less frequently proteinase-3 (PR3)-ANCAs (p = 0.078). Univariate analysis identified higher age (p = 0.022), lower serum albumin (p = 0.030), lack of statin therapy (p = 0.009), and rituximab treatment (p = 0.018) as significant risk factors of VTE. In multivariate analysis, only lack of statin therapy (HR 4.873; p = 0.042) was significantly associated with VTE. (4) Conclusion: Patients with ANCA-GN are at high risk of VTE, especially within the first months following AAV diagnosis. Our results suggest that statin therapy is associated with a lower risk of VTE in ANCA-GN patients. MDPI 2020-09-30 /pmc/articles/PMC7599765/ /pubmed/33007967 http://dx.doi.org/10.3390/jcm9103177 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Henry, Nicolas
Brilland, Benoit
Wacrenier, Samuel
Djema, Assia
Garnier, Anne Sophie
Gansey, Renaud
Coindre, Jean-Philippe
Besson, Virginie
Duveau, Agnès
Subra, Jean-François
Cousin, Maud
Piccoli, Giorgina Barbara
Augusto, Jean-François
Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry
title Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry
title_full Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry
title_fullStr Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry
title_full_unstemmed Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry
title_short Incidence and Risk Factors of Venous Thromboembolic Events in Patients with ANCA-Glomerulonephritis: A Cohort Study from the Maine-Anjou Registry
title_sort incidence and risk factors of venous thromboembolic events in patients with anca-glomerulonephritis: a cohort study from the maine-anjou registry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599765/
https://www.ncbi.nlm.nih.gov/pubmed/33007967
http://dx.doi.org/10.3390/jcm9103177
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