Cargando…

Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice

Low 25-OH serum vitamin D (VitD) is pervasive in older adults and linked to functional decline and progression of frailty. We have previously shown that chronic VitD insufficiency in “middle-aged” mice results in impaired anaerobic exercise capacity, decreased lean mass, and increased adiposity. Her...

Descripción completa

Detalles Bibliográficos
Autores principales: Seldeen, Kenneth Ladd, Berman, Reem Nagi, Pang, Manhui, Lasky, Ginger, Weiss, Carleara, MacDonald, Brian Alexander, Thiyagarajan, Ramkumar, Redae, Yonas, Troen, Bruce Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599884/
https://www.ncbi.nlm.nih.gov/pubmed/33007912
http://dx.doi.org/10.3390/nu12103005
_version_ 1783602991590277120
author Seldeen, Kenneth Ladd
Berman, Reem Nagi
Pang, Manhui
Lasky, Ginger
Weiss, Carleara
MacDonald, Brian Alexander
Thiyagarajan, Ramkumar
Redae, Yonas
Troen, Bruce Robert
author_facet Seldeen, Kenneth Ladd
Berman, Reem Nagi
Pang, Manhui
Lasky, Ginger
Weiss, Carleara
MacDonald, Brian Alexander
Thiyagarajan, Ramkumar
Redae, Yonas
Troen, Bruce Robert
author_sort Seldeen, Kenneth Ladd
collection PubMed
description Low 25-OH serum vitamin D (VitD) is pervasive in older adults and linked to functional decline and progression of frailty. We have previously shown that chronic VitD insufficiency in “middle-aged” mice results in impaired anaerobic exercise capacity, decreased lean mass, and increased adiposity. Here, we examine if VitD insufficiency results in similar deficits and greater frailty progression in old-aged (24 to 28 months of age) mice. Similar to what we report in younger mice, older mice exhibit a rapid and sustained response in serum 25-OH VitD levels to differential supplementation, including insufficient (125 IU/kg chow), sufficient (1000 IU/kg chow), and hypersufficient (8000 IU/kg chow) groups. During the 4-month time course, mice were assessed for body composition (DEXA), physical performance, and frailty using a Fried physical phenotype-based assessment tool. The 125 IU mice exhibited worse grip strength (p = 0.002) and inverted grip hang time (p = 0.003) at endpoint and the 8000 IU mice transiently displayed greater rotarod performance after 3 months (p = 0.012), yet other aspects including treadmill performance and gait speed were unaffected. However, 125 and 1000 IU mice exhibited greater frailty compared to baseline (p = 0.001 and p = 0.038, respectively), whereas 8000 IU mice did not (p = 0.341). These data indicate targeting higher serum 25-OH vitamin D levels may attenuate frailty progression during aging.
format Online
Article
Text
id pubmed-7599884
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75998842020-11-01 Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice Seldeen, Kenneth Ladd Berman, Reem Nagi Pang, Manhui Lasky, Ginger Weiss, Carleara MacDonald, Brian Alexander Thiyagarajan, Ramkumar Redae, Yonas Troen, Bruce Robert Nutrients Article Low 25-OH serum vitamin D (VitD) is pervasive in older adults and linked to functional decline and progression of frailty. We have previously shown that chronic VitD insufficiency in “middle-aged” mice results in impaired anaerobic exercise capacity, decreased lean mass, and increased adiposity. Here, we examine if VitD insufficiency results in similar deficits and greater frailty progression in old-aged (24 to 28 months of age) mice. Similar to what we report in younger mice, older mice exhibit a rapid and sustained response in serum 25-OH VitD levels to differential supplementation, including insufficient (125 IU/kg chow), sufficient (1000 IU/kg chow), and hypersufficient (8000 IU/kg chow) groups. During the 4-month time course, mice were assessed for body composition (DEXA), physical performance, and frailty using a Fried physical phenotype-based assessment tool. The 125 IU mice exhibited worse grip strength (p = 0.002) and inverted grip hang time (p = 0.003) at endpoint and the 8000 IU mice transiently displayed greater rotarod performance after 3 months (p = 0.012), yet other aspects including treadmill performance and gait speed were unaffected. However, 125 and 1000 IU mice exhibited greater frailty compared to baseline (p = 0.001 and p = 0.038, respectively), whereas 8000 IU mice did not (p = 0.341). These data indicate targeting higher serum 25-OH vitamin D levels may attenuate frailty progression during aging. MDPI 2020-09-30 /pmc/articles/PMC7599884/ /pubmed/33007912 http://dx.doi.org/10.3390/nu12103005 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seldeen, Kenneth Ladd
Berman, Reem Nagi
Pang, Manhui
Lasky, Ginger
Weiss, Carleara
MacDonald, Brian Alexander
Thiyagarajan, Ramkumar
Redae, Yonas
Troen, Bruce Robert
Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice
title Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice
title_full Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice
title_fullStr Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice
title_full_unstemmed Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice
title_short Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice
title_sort vitamin d insufficiency reduces grip strength, grip endurance and increases frailty in aged c57bl/6j mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599884/
https://www.ncbi.nlm.nih.gov/pubmed/33007912
http://dx.doi.org/10.3390/nu12103005
work_keys_str_mv AT seldeenkennethladd vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice
AT bermanreemnagi vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice
AT pangmanhui vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice
AT laskyginger vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice
AT weisscarleara vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice
AT macdonaldbrianalexander vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice
AT thiyagarajanramkumar vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice
AT redaeyonas vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice
AT troenbrucerobert vitamindinsufficiencyreducesgripstrengthgripenduranceandincreasesfrailtyinagedc57bl6jmice