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Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women

Background: Bariatric surgery is proven to change eating behavior and cause sustained weight loss, yet the exact mechanisms underlying these changes are not clearly understood. We explore this in a novel way by examining how bariatric surgery affects the brain–gut–microbiome (BGM) axis. Methods: Pat...

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Autores principales: Dong, Tien S., Gupta, Arpana, Jacobs, Jonathan P., Lagishetty, Venu, Gallagher, Elizabeth, Bhatt, Ravi R., Vora, Priten, Osadchiy, Vadim, Stains, Jean, Balioukova, Anna, Chen, Yijun, Dutson, Erik, Mayer, Emeran A., Sanmiguel, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599899/
https://www.ncbi.nlm.nih.gov/pubmed/32987837
http://dx.doi.org/10.3390/nu12102924
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author Dong, Tien S.
Gupta, Arpana
Jacobs, Jonathan P.
Lagishetty, Venu
Gallagher, Elizabeth
Bhatt, Ravi R.
Vora, Priten
Osadchiy, Vadim
Stains, Jean
Balioukova, Anna
Chen, Yijun
Dutson, Erik
Mayer, Emeran A.
Sanmiguel, Claudia
author_facet Dong, Tien S.
Gupta, Arpana
Jacobs, Jonathan P.
Lagishetty, Venu
Gallagher, Elizabeth
Bhatt, Ravi R.
Vora, Priten
Osadchiy, Vadim
Stains, Jean
Balioukova, Anna
Chen, Yijun
Dutson, Erik
Mayer, Emeran A.
Sanmiguel, Claudia
author_sort Dong, Tien S.
collection PubMed
description Background: Bariatric surgery is proven to change eating behavior and cause sustained weight loss, yet the exact mechanisms underlying these changes are not clearly understood. We explore this in a novel way by examining how bariatric surgery affects the brain–gut–microbiome (BGM) axis. Methods: Patient demographics, serum, stool, eating behavior questionnaires, and brain magnetic resonance imaging (MRI) were collected before and 6 months after laparoscopic sleeve gastrectomy (LSG). Differences in eating behavior and brain morphology and resting-state functional connectivity in core reward regions were correlated with serum metabolite and 16S microbiome data. Results: LSG resulted in significant weight loss and improvement in maladaptive eating behaviors as measured by the Yale Food Addiction Scale (YFAS). Brain imaging showed a significant increase in brain volume of the putamen (p.adj < 0.05) and amygdala (p.adj < 0.05) after surgery. Resting-state connectivity between the precuneus and the putamen was significantly reduced after LSG (p.adj = 0.046). This change was associated with YFAS symptom count. Bacteroides, Ruminococcus, and Holdemanella were associated with reduced connectivity between these areas. Metabolomic profiles showed a positive correlation between this brain connection and a phosphatidylcholine metabolite. Conclusion: Bariatric surgery modulates brain networks that affect eating behavior, potentially through effects on the gut microbiota and its metabolites.
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spelling pubmed-75998992020-11-01 Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women Dong, Tien S. Gupta, Arpana Jacobs, Jonathan P. Lagishetty, Venu Gallagher, Elizabeth Bhatt, Ravi R. Vora, Priten Osadchiy, Vadim Stains, Jean Balioukova, Anna Chen, Yijun Dutson, Erik Mayer, Emeran A. Sanmiguel, Claudia Nutrients Article Background: Bariatric surgery is proven to change eating behavior and cause sustained weight loss, yet the exact mechanisms underlying these changes are not clearly understood. We explore this in a novel way by examining how bariatric surgery affects the brain–gut–microbiome (BGM) axis. Methods: Patient demographics, serum, stool, eating behavior questionnaires, and brain magnetic resonance imaging (MRI) were collected before and 6 months after laparoscopic sleeve gastrectomy (LSG). Differences in eating behavior and brain morphology and resting-state functional connectivity in core reward regions were correlated with serum metabolite and 16S microbiome data. Results: LSG resulted in significant weight loss and improvement in maladaptive eating behaviors as measured by the Yale Food Addiction Scale (YFAS). Brain imaging showed a significant increase in brain volume of the putamen (p.adj < 0.05) and amygdala (p.adj < 0.05) after surgery. Resting-state connectivity between the precuneus and the putamen was significantly reduced after LSG (p.adj = 0.046). This change was associated with YFAS symptom count. Bacteroides, Ruminococcus, and Holdemanella were associated with reduced connectivity between these areas. Metabolomic profiles showed a positive correlation between this brain connection and a phosphatidylcholine metabolite. Conclusion: Bariatric surgery modulates brain networks that affect eating behavior, potentially through effects on the gut microbiota and its metabolites. MDPI 2020-09-24 /pmc/articles/PMC7599899/ /pubmed/32987837 http://dx.doi.org/10.3390/nu12102924 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dong, Tien S.
Gupta, Arpana
Jacobs, Jonathan P.
Lagishetty, Venu
Gallagher, Elizabeth
Bhatt, Ravi R.
Vora, Priten
Osadchiy, Vadim
Stains, Jean
Balioukova, Anna
Chen, Yijun
Dutson, Erik
Mayer, Emeran A.
Sanmiguel, Claudia
Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women
title Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women
title_full Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women
title_fullStr Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women
title_full_unstemmed Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women
title_short Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women
title_sort improvement in uncontrolled eating behavior after laparoscopic sleeve gastrectomy is associated with alterations in the brain–gut–microbiome axis in obese women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7599899/
https://www.ncbi.nlm.nih.gov/pubmed/32987837
http://dx.doi.org/10.3390/nu12102924
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