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Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma

Pancreatic intraepithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasms (IPMNs) are common pancreatic adenocarcinoma precursor lesions. However, data regarding their respective associations with survival rate and prognosis are lacking. We retrospectively evaluated 72 pancreatic ad...

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Autores principales: McGinnis, Timothy, Bantis, Leonidas E., Madan, Rashna, Dandawate, Prasad, Kumer, Sean, Schmitt, Timothy, Paluri, Ravi Kumar, Kasi, Anup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600023/
https://www.ncbi.nlm.nih.gov/pubmed/32992976
http://dx.doi.org/10.3390/jcm9103102
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author McGinnis, Timothy
Bantis, Leonidas E.
Madan, Rashna
Dandawate, Prasad
Kumer, Sean
Schmitt, Timothy
Paluri, Ravi Kumar
Kasi, Anup
author_facet McGinnis, Timothy
Bantis, Leonidas E.
Madan, Rashna
Dandawate, Prasad
Kumer, Sean
Schmitt, Timothy
Paluri, Ravi Kumar
Kasi, Anup
author_sort McGinnis, Timothy
collection PubMed
description Pancreatic intraepithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasms (IPMNs) are common pancreatic adenocarcinoma precursor lesions. However, data regarding their respective associations with survival rate and prognosis are lacking. We retrospectively evaluated 72 pancreatic adenocarcinoma tumor resection patients at the University of Kansas Hospital between August 2009 and March 2019. Patients were divided into one of two groups, PanIN or IPMN, based on the results of the surgical pathology report. We compared baseline characteristics, overall survival (OS), and progression free survival (PFS) between the two groups, as well as OS and PFS based on local or distant tumor recurrence for both groups combined. 52 patients had PanINs and 20 patients had IPMNs. Patients who had an IPMN precursor lesion had better median PFS and OS when compared to patients with PanIN precursor lesions. However, the location of tumor recurrence (local or distant) did not show a statistically significant difference in OS.
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spelling pubmed-76000232020-11-01 Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma McGinnis, Timothy Bantis, Leonidas E. Madan, Rashna Dandawate, Prasad Kumer, Sean Schmitt, Timothy Paluri, Ravi Kumar Kasi, Anup J Clin Med Article Pancreatic intraepithelial neoplasms (PanINs) and intraductal papillary mucinous neoplasms (IPMNs) are common pancreatic adenocarcinoma precursor lesions. However, data regarding their respective associations with survival rate and prognosis are lacking. We retrospectively evaluated 72 pancreatic adenocarcinoma tumor resection patients at the University of Kansas Hospital between August 2009 and March 2019. Patients were divided into one of two groups, PanIN or IPMN, based on the results of the surgical pathology report. We compared baseline characteristics, overall survival (OS), and progression free survival (PFS) between the two groups, as well as OS and PFS based on local or distant tumor recurrence for both groups combined. 52 patients had PanINs and 20 patients had IPMNs. Patients who had an IPMN precursor lesion had better median PFS and OS when compared to patients with PanIN precursor lesions. However, the location of tumor recurrence (local or distant) did not show a statistically significant difference in OS. MDPI 2020-09-25 /pmc/articles/PMC7600023/ /pubmed/32992976 http://dx.doi.org/10.3390/jcm9103102 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
McGinnis, Timothy
Bantis, Leonidas E.
Madan, Rashna
Dandawate, Prasad
Kumer, Sean
Schmitt, Timothy
Paluri, Ravi Kumar
Kasi, Anup
Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma
title Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma
title_full Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma
title_fullStr Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma
title_full_unstemmed Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma
title_short Survival Outcomes of Pancreatic Intraepithelial Neoplasm (PanIN) versus Intraductal Papillary Mucinous Neoplasm (IPMN) Associated Pancreatic Adenocarcinoma
title_sort survival outcomes of pancreatic intraepithelial neoplasm (panin) versus intraductal papillary mucinous neoplasm (ipmn) associated pancreatic adenocarcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600023/
https://www.ncbi.nlm.nih.gov/pubmed/32992976
http://dx.doi.org/10.3390/jcm9103102
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