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Astrocytic Factors Controlling Synaptogenesis: A Team Play

Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brai...

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Detalles Bibliográficos
Autores principales: Fossati, Giuliana, Matteoli, Michela, Menna, Elisabetta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600026/
https://www.ncbi.nlm.nih.gov/pubmed/32993090
http://dx.doi.org/10.3390/cells9102173
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author Fossati, Giuliana
Matteoli, Michela
Menna, Elisabetta
author_facet Fossati, Giuliana
Matteoli, Michela
Menna, Elisabetta
author_sort Fossati, Giuliana
collection PubMed
description Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, causing neurological or neuropsychiatric conditions. Recent findings revealed a huge astrocyte heterogeneity among different brain areas, which is likely at the foundation of the different synaptogenic potential of these cells in selected brain regions. This review highlights recent findings on novel mechanisms that regulate astrocyte-mediated synaptogenesis during development, and the control of synapse number in the critical period or upon synaptic plasticity.
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spelling pubmed-76000262020-11-01 Astrocytic Factors Controlling Synaptogenesis: A Team Play Fossati, Giuliana Matteoli, Michela Menna, Elisabetta Cells Review Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, causing neurological or neuropsychiatric conditions. Recent findings revealed a huge astrocyte heterogeneity among different brain areas, which is likely at the foundation of the different synaptogenic potential of these cells in selected brain regions. This review highlights recent findings on novel mechanisms that regulate astrocyte-mediated synaptogenesis during development, and the control of synapse number in the critical period or upon synaptic plasticity. MDPI 2020-09-26 /pmc/articles/PMC7600026/ /pubmed/32993090 http://dx.doi.org/10.3390/cells9102173 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fossati, Giuliana
Matteoli, Michela
Menna, Elisabetta
Astrocytic Factors Controlling Synaptogenesis: A Team Play
title Astrocytic Factors Controlling Synaptogenesis: A Team Play
title_full Astrocytic Factors Controlling Synaptogenesis: A Team Play
title_fullStr Astrocytic Factors Controlling Synaptogenesis: A Team Play
title_full_unstemmed Astrocytic Factors Controlling Synaptogenesis: A Team Play
title_short Astrocytic Factors Controlling Synaptogenesis: A Team Play
title_sort astrocytic factors controlling synaptogenesis: a team play
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600026/
https://www.ncbi.nlm.nih.gov/pubmed/32993090
http://dx.doi.org/10.3390/cells9102173
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