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Astrocytic Factors Controlling Synaptogenesis: A Team Play
Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brai...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600026/ https://www.ncbi.nlm.nih.gov/pubmed/32993090 http://dx.doi.org/10.3390/cells9102173 |
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author | Fossati, Giuliana Matteoli, Michela Menna, Elisabetta |
author_facet | Fossati, Giuliana Matteoli, Michela Menna, Elisabetta |
author_sort | Fossati, Giuliana |
collection | PubMed |
description | Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, causing neurological or neuropsychiatric conditions. Recent findings revealed a huge astrocyte heterogeneity among different brain areas, which is likely at the foundation of the different synaptogenic potential of these cells in selected brain regions. This review highlights recent findings on novel mechanisms that regulate astrocyte-mediated synaptogenesis during development, and the control of synapse number in the critical period or upon synaptic plasticity. |
format | Online Article Text |
id | pubmed-7600026 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76000262020-11-01 Astrocytic Factors Controlling Synaptogenesis: A Team Play Fossati, Giuliana Matteoli, Michela Menna, Elisabetta Cells Review Astrocytes are essential players in brain circuit development and homeostasis, controlling many aspects of synapse formation, function, plasticity and elimination both during development and adulthood. Accordingly, alterations in astrocyte morphogenesis and physiology may severely affect proper brain development, causing neurological or neuropsychiatric conditions. Recent findings revealed a huge astrocyte heterogeneity among different brain areas, which is likely at the foundation of the different synaptogenic potential of these cells in selected brain regions. This review highlights recent findings on novel mechanisms that regulate astrocyte-mediated synaptogenesis during development, and the control of synapse number in the critical period or upon synaptic plasticity. MDPI 2020-09-26 /pmc/articles/PMC7600026/ /pubmed/32993090 http://dx.doi.org/10.3390/cells9102173 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fossati, Giuliana Matteoli, Michela Menna, Elisabetta Astrocytic Factors Controlling Synaptogenesis: A Team Play |
title | Astrocytic Factors Controlling Synaptogenesis: A Team Play |
title_full | Astrocytic Factors Controlling Synaptogenesis: A Team Play |
title_fullStr | Astrocytic Factors Controlling Synaptogenesis: A Team Play |
title_full_unstemmed | Astrocytic Factors Controlling Synaptogenesis: A Team Play |
title_short | Astrocytic Factors Controlling Synaptogenesis: A Team Play |
title_sort | astrocytic factors controlling synaptogenesis: a team play |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600026/ https://www.ncbi.nlm.nih.gov/pubmed/32993090 http://dx.doi.org/10.3390/cells9102173 |
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