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Classical Examples of the Concept of the ASIA Syndrome

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant agent exposure. Since the recognition of ASIA syndrom...

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Autores principales: Borba, Vânia, Malkova, Anna, Basantsova, Natalia, Halpert, Gilad, Andreoli, Laura, Tincani, Angela, Amital, Howard, Shoenfeld, Yehuda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600067/
https://www.ncbi.nlm.nih.gov/pubmed/33053910
http://dx.doi.org/10.3390/biom10101436
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author Borba, Vânia
Malkova, Anna
Basantsova, Natalia
Halpert, Gilad
Andreoli, Laura
Tincani, Angela
Amital, Howard
Shoenfeld, Yehuda
author_facet Borba, Vânia
Malkova, Anna
Basantsova, Natalia
Halpert, Gilad
Andreoli, Laura
Tincani, Angela
Amital, Howard
Shoenfeld, Yehuda
author_sort Borba, Vânia
collection PubMed
description Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant agent exposure. Since the recognition of ASIA syndrome, more than 4400 documented cases have been reported so far, illustrated by heterogeneous clinical manifestations and severity. In this review, five enigmatic conditions, including sarcoidosis, Sjögren’s syndrome, undifferentiated connective tissue disease, silicone implant incompatibility syndrome (SIIS), and immune-related adverse events (irAEs), are defined as classical examples of ASIA. Certainly, these disorders have been described after an adjuvant stimulus (silicone implantation, drugs, infections, metals, vaccines, etc.) among genetically predisposed individuals (mainly the HLA-DRB1 and PTPN22 gene), which induce an hyperstimulation of the immune system resulting in the production of autoantibodies, eventually leading to the development of autoimmune diseases. Circulating autonomic autoantibodies in the sera of patients with silicone breast implants, as well as anatomopathological aspects of small fiber neuropathy in their skin biopsies have been recently described. To our knowledge, these novel insights serve as a common explanation to the non-specific clinical manifestations reported in patients with ASIA, leading to the redefinition of the ASIA syndrome diagnostic criteria.
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spelling pubmed-76000672020-11-01 Classical Examples of the Concept of the ASIA Syndrome Borba, Vânia Malkova, Anna Basantsova, Natalia Halpert, Gilad Andreoli, Laura Tincani, Angela Amital, Howard Shoenfeld, Yehuda Biomolecules Review Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant agent exposure. Since the recognition of ASIA syndrome, more than 4400 documented cases have been reported so far, illustrated by heterogeneous clinical manifestations and severity. In this review, five enigmatic conditions, including sarcoidosis, Sjögren’s syndrome, undifferentiated connective tissue disease, silicone implant incompatibility syndrome (SIIS), and immune-related adverse events (irAEs), are defined as classical examples of ASIA. Certainly, these disorders have been described after an adjuvant stimulus (silicone implantation, drugs, infections, metals, vaccines, etc.) among genetically predisposed individuals (mainly the HLA-DRB1 and PTPN22 gene), which induce an hyperstimulation of the immune system resulting in the production of autoantibodies, eventually leading to the development of autoimmune diseases. Circulating autonomic autoantibodies in the sera of patients with silicone breast implants, as well as anatomopathological aspects of small fiber neuropathy in their skin biopsies have been recently described. To our knowledge, these novel insights serve as a common explanation to the non-specific clinical manifestations reported in patients with ASIA, leading to the redefinition of the ASIA syndrome diagnostic criteria. MDPI 2020-10-12 /pmc/articles/PMC7600067/ /pubmed/33053910 http://dx.doi.org/10.3390/biom10101436 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Borba, Vânia
Malkova, Anna
Basantsova, Natalia
Halpert, Gilad
Andreoli, Laura
Tincani, Angela
Amital, Howard
Shoenfeld, Yehuda
Classical Examples of the Concept of the ASIA Syndrome
title Classical Examples of the Concept of the ASIA Syndrome
title_full Classical Examples of the Concept of the ASIA Syndrome
title_fullStr Classical Examples of the Concept of the ASIA Syndrome
title_full_unstemmed Classical Examples of the Concept of the ASIA Syndrome
title_short Classical Examples of the Concept of the ASIA Syndrome
title_sort classical examples of the concept of the asia syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600067/
https://www.ncbi.nlm.nih.gov/pubmed/33053910
http://dx.doi.org/10.3390/biom10101436
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