[D-Leu(1)]MC-LR Has Lower PP1 Inhibitory Capability and Greater Toxic Potency than MC-LR in Animal and Plant Tissues

Two microcystins, MC-LR and [D-Leu(1)]MC-LR, present in La Plata Basin blooms, are differentiated by substitution of D-Alanine for D-Leucine at position 1. Our objective was to evaluate acute toxicity of [D-Leu(1)]MC-LR and MC-LR in mice (N:NIH Swiss) and beans (Phaseolus vulgaris). We observed vari...

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Detalles Bibliográficos
Autores principales: Sedan, Daniela, Malaissi, Luciano, Vaccarini, Cristian Adrián, Ventosi, Ezequiel, Laguens, Martín, Rosso, Lorena, Giannuzzi, Leda, Andrinolo, Darío
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600089/
https://www.ncbi.nlm.nih.gov/pubmed/33019556
http://dx.doi.org/10.3390/toxins12100632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600089/
https://www.ncbi.nlm.nih.gov/pubmed/33019556
http://dx.doi.org/10.3390/toxins12100632

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