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Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy

The breeding of meat rabbits is an important sector in the livestock industry in Italy. The focus of this study was to describe the antibiotic resistance profile distribution among the Methicillin-sensitive Staphylococcus aureus isolated in a rabbit farm. From 400 animals of different ages and three...

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Autores principales: Attili, Anna-Rita, Bellato, Alessandro, Robino, Patrizia, Galosi, Livio, Papeschi, Cristiano, Rossi, Giacomo, Fileni, Eleonora, Linardi, Martina, Cuteri, Vincenzo, Chiesa, Francesco, Nebbia, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600096/
https://www.ncbi.nlm.nih.gov/pubmed/33027900
http://dx.doi.org/10.3390/antibiotics9100673
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author Attili, Anna-Rita
Bellato, Alessandro
Robino, Patrizia
Galosi, Livio
Papeschi, Cristiano
Rossi, Giacomo
Fileni, Eleonora
Linardi, Martina
Cuteri, Vincenzo
Chiesa, Francesco
Nebbia, Patrizia
author_facet Attili, Anna-Rita
Bellato, Alessandro
Robino, Patrizia
Galosi, Livio
Papeschi, Cristiano
Rossi, Giacomo
Fileni, Eleonora
Linardi, Martina
Cuteri, Vincenzo
Chiesa, Francesco
Nebbia, Patrizia
author_sort Attili, Anna-Rita
collection PubMed
description The breeding of meat rabbits is an important sector in the livestock industry in Italy. The focus of this study was to describe the antibiotic resistance profile distribution among the Methicillin-sensitive Staphylococcus aureus isolated in a rabbit farm. From 400 animals of different ages and three farm workers, 96 randomly selected strains isolated from various anatomical sites and lesions were analysed. According to spa typing and the resistance profiles towards veterinary and human antibiotics, 26 pathotypes were identified. The highest resistance was observed against Tetracyclines (92.3%) and Macrolides (80.8%), while almost all were susceptible to Penicillins, according to the limited use of β-lactams on the farm. In total, 92.3% of pathotypes were multidrug resistant (MDRs). Two MDR pathotypes belonging to the t2802 spa type were isolated from both farmers and rabbits. Age categories harboured significantly different pathotypes (p = 0.019), while no association was found between pathotypes and lesions (p = 0.128) or sampling sites (p = 0.491). The antibiotic resistance was observed to increase with the time spent in the farm environment (age category). The selective pressure exerted by antibiotic use acted by giving advantage to more resistant strains rather than by lowering susceptibility to various drug categories within strains.
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spelling pubmed-76000962020-11-01 Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy Attili, Anna-Rita Bellato, Alessandro Robino, Patrizia Galosi, Livio Papeschi, Cristiano Rossi, Giacomo Fileni, Eleonora Linardi, Martina Cuteri, Vincenzo Chiesa, Francesco Nebbia, Patrizia Antibiotics (Basel) Article The breeding of meat rabbits is an important sector in the livestock industry in Italy. The focus of this study was to describe the antibiotic resistance profile distribution among the Methicillin-sensitive Staphylococcus aureus isolated in a rabbit farm. From 400 animals of different ages and three farm workers, 96 randomly selected strains isolated from various anatomical sites and lesions were analysed. According to spa typing and the resistance profiles towards veterinary and human antibiotics, 26 pathotypes were identified. The highest resistance was observed against Tetracyclines (92.3%) and Macrolides (80.8%), while almost all were susceptible to Penicillins, according to the limited use of β-lactams on the farm. In total, 92.3% of pathotypes were multidrug resistant (MDRs). Two MDR pathotypes belonging to the t2802 spa type were isolated from both farmers and rabbits. Age categories harboured significantly different pathotypes (p = 0.019), while no association was found between pathotypes and lesions (p = 0.128) or sampling sites (p = 0.491). The antibiotic resistance was observed to increase with the time spent in the farm environment (age category). The selective pressure exerted by antibiotic use acted by giving advantage to more resistant strains rather than by lowering susceptibility to various drug categories within strains. MDPI 2020-10-05 /pmc/articles/PMC7600096/ /pubmed/33027900 http://dx.doi.org/10.3390/antibiotics9100673 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Attili, Anna-Rita
Bellato, Alessandro
Robino, Patrizia
Galosi, Livio
Papeschi, Cristiano
Rossi, Giacomo
Fileni, Eleonora
Linardi, Martina
Cuteri, Vincenzo
Chiesa, Francesco
Nebbia, Patrizia
Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy
title Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy
title_full Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy
title_fullStr Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy
title_full_unstemmed Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy
title_short Analysis of the Antibiotic Resistance Profiles in Methicillin-Sensitive S. aureus Pathotypes Isolated on a Commercial Rabbit Farm in Italy
title_sort analysis of the antibiotic resistance profiles in methicillin-sensitive s. aureus pathotypes isolated on a commercial rabbit farm in italy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600096/
https://www.ncbi.nlm.nih.gov/pubmed/33027900
http://dx.doi.org/10.3390/antibiotics9100673
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