Genetic Variation and Autism: A Field Synopsis and Systematic Meta-Analysis

This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched fr...

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Detalles Bibliográficos
Autores principales: Lee, Jinhee, Son, Min Ji, Son, Chei Yun, Jeong, Gwang Hun, Lee, Keum Hwa, Lee, Kwang Seob, Ko, Younhee, Kim, Jong Yeob, Lee, Jun Young, Radua, Joaquim, Eisenhut, Michael, Gressier, Florence, Koyanagi, Ai, Stubbs, Brendon, Solmi, Marco, Rais, Theodor B., Kronbichler, Andreas, Dragioti, Elena, Vasconcelos, Daniel Fernando Pereira, da Silva, Felipe Rodolfo Pereira, Tizaoui, Kalthoum, Brunoni, André Russowsky, Carvalho, Andre F., Cargnin, Sarah, Terrazzino, Salvatore, Stickley, Andrew, Smith, Lee, Thompson, Trevor, Shin, Jae Il, Fusar-Poli, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600188/
https://www.ncbi.nlm.nih.gov/pubmed/33007889
http://dx.doi.org/10.3390/brainsci10100692
Descripción
Sumario:This study aimed to verify noteworthy findings between genetic risk factors and autism spectrum disorder (ASD) by employing the false positive report probability (FPRP) and the Bayesian false-discovery probability (BFDP). PubMed and the Genome-Wide Association Studies (GWAS) catalog were searched from inception to 1 August, 2019. We included meta-analyses on genetic factors of ASD of any study design. Overall, twenty-seven meta-analyses articles from literature searches, and four manually added articles from the GWAS catalog were re-analyzed. This showed that five of 31 comparisons for meta-analyses of observational studies, 40 out of 203 comparisons for the GWAS meta-analyses, and 18 out of 20 comparisons for the GWAS catalog, respectively, had noteworthy estimations under both Bayesian approaches. In this study, we found noteworthy genetic comparisons highly related to an increased risk of ASD. Multiple genetic comparisons were shown to be associated with ASD risk; however, genuine associations should be carefully verified and understood.

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