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Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients

Oral squamous cell carcinoma (OSCC) is the most common secondary solid malignancy after hematopoietic stem-cell transplantation (HSCT). OSCC following HSCT is frequently preceded by chronic graft-versus-host disease (cGVHD). The aim of this study was to describe a cohort of post-HSCT patients and to...

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Autores principales: Leuci, Stefania, Coppola, Noemi, Blasi, Andrea, Ruoppo, Elvira, Bizzoca, Maria Eleonora, Lo Muzio, Lorenzo, Marano, Luana, Risitano, Antonio Maria, Mignogna, Michele Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600275/
https://www.ncbi.nlm.nih.gov/pubmed/33050268
http://dx.doi.org/10.3390/life10100236
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author Leuci, Stefania
Coppola, Noemi
Blasi, Andrea
Ruoppo, Elvira
Bizzoca, Maria Eleonora
Lo Muzio, Lorenzo
Marano, Luana
Risitano, Antonio Maria
Mignogna, Michele Davide
author_facet Leuci, Stefania
Coppola, Noemi
Blasi, Andrea
Ruoppo, Elvira
Bizzoca, Maria Eleonora
Lo Muzio, Lorenzo
Marano, Luana
Risitano, Antonio Maria
Mignogna, Michele Davide
author_sort Leuci, Stefania
collection PubMed
description Oral squamous cell carcinoma (OSCC) is the most common secondary solid malignancy after hematopoietic stem-cell transplantation (HSCT). OSCC following HSCT is frequently preceded by chronic graft-versus-host disease (cGVHD). The aim of this study was to describe a cohort of post-HSCT patients and to evaluate the onset of oral epithelial dysplasia and/or OSCC over time. In this retrospective cohort study, we present a cohort of hematological patients that underwent HSCT. Demographic variables, clinical hematological data, data regarding acute graft-versus-host disease (aGVHD) and cGVHD, and oral clinical features were analyzed. We focused on clinicopathological features of a subgroup of 22 patients with oral cGVHD and OSCC after HSCT. Among 80 included patients, 46 patients (57.5%) developed aGVHD and 39 patients (48.7%) developed cGVHD. Oral mucosa was involved in 17 patients with aGVHD (36.9%) and in 22 patients (56.4%) with cGVHD. Out of a total of 22 oral biopsies, roughly 40% revealed mild to moderate dysplasia, and 32% were OSCC. In the absence of international agreement on the best timing of oral follow-up after HSCT, it is mandatory to establish a close multidisciplinary evaluation in order to prevent the onset of HSCT-related OSCC and to reduce post-transplant mortality due to secondary tumors.
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spelling pubmed-76002752020-11-01 Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients Leuci, Stefania Coppola, Noemi Blasi, Andrea Ruoppo, Elvira Bizzoca, Maria Eleonora Lo Muzio, Lorenzo Marano, Luana Risitano, Antonio Maria Mignogna, Michele Davide Life (Basel) Article Oral squamous cell carcinoma (OSCC) is the most common secondary solid malignancy after hematopoietic stem-cell transplantation (HSCT). OSCC following HSCT is frequently preceded by chronic graft-versus-host disease (cGVHD). The aim of this study was to describe a cohort of post-HSCT patients and to evaluate the onset of oral epithelial dysplasia and/or OSCC over time. In this retrospective cohort study, we present a cohort of hematological patients that underwent HSCT. Demographic variables, clinical hematological data, data regarding acute graft-versus-host disease (aGVHD) and cGVHD, and oral clinical features were analyzed. We focused on clinicopathological features of a subgroup of 22 patients with oral cGVHD and OSCC after HSCT. Among 80 included patients, 46 patients (57.5%) developed aGVHD and 39 patients (48.7%) developed cGVHD. Oral mucosa was involved in 17 patients with aGVHD (36.9%) and in 22 patients (56.4%) with cGVHD. Out of a total of 22 oral biopsies, roughly 40% revealed mild to moderate dysplasia, and 32% were OSCC. In the absence of international agreement on the best timing of oral follow-up after HSCT, it is mandatory to establish a close multidisciplinary evaluation in order to prevent the onset of HSCT-related OSCC and to reduce post-transplant mortality due to secondary tumors. MDPI 2020-10-09 /pmc/articles/PMC7600275/ /pubmed/33050268 http://dx.doi.org/10.3390/life10100236 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Leuci, Stefania
Coppola, Noemi
Blasi, Andrea
Ruoppo, Elvira
Bizzoca, Maria Eleonora
Lo Muzio, Lorenzo
Marano, Luana
Risitano, Antonio Maria
Mignogna, Michele Davide
Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients
title Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients
title_full Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients
title_fullStr Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients
title_full_unstemmed Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients
title_short Oral Dysplastic Complications after HSCT: Single Case Series of Multidisciplinary Evaluation of 80 Patients
title_sort oral dysplastic complications after hsct: single case series of multidisciplinary evaluation of 80 patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600275/
https://www.ncbi.nlm.nih.gov/pubmed/33050268
http://dx.doi.org/10.3390/life10100236
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