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Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?

Recently, nutritional interventions have received attention as promising approaches to promote human health during a lifespan. The Mediterranean and Okinawan diets have been associated with longevity and decreasing risk for age-related diseases in contrast to the Western diet. The effect might be du...

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Autores principales: Varghese, Nimmy, Werner, Selina, Grimm, Amandine, Eckert, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600282/
https://www.ncbi.nlm.nih.gov/pubmed/33003315
http://dx.doi.org/10.3390/antiox9100932
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author Varghese, Nimmy
Werner, Selina
Grimm, Amandine
Eckert, Anne
author_facet Varghese, Nimmy
Werner, Selina
Grimm, Amandine
Eckert, Anne
author_sort Varghese, Nimmy
collection PubMed
description Recently, nutritional interventions have received attention as promising approaches to promote human health during a lifespan. The Mediterranean and Okinawan diets have been associated with longevity and decreasing risk for age-related diseases in contrast to the Western diet. The effect might be due to several antioxidative bioactive compounds highly consumed in both diets, namely, resveratrol, hydroxytyrosol, oleuropein, curcumin, and spermidine. This review aims to address the underlying mechanisms of these compounds to enhance mental fitness throughout life with a focus on brain mitophagy. Mitophagy is the autophagic clearance of dysfunctional, redundant, and aged mitochondria. In aging and neurodegenerative disorders, mitophagy is crucial to preserve the autophagy mechanism of the whole cell, especially during oxidative stress. Growing evidence indicates that curcumin, astaxanthin, resveratrol, hydroxytyrosol, oleuropein, and spermidine might exert protective functions via antioxidative properties and as well the enhanced induction of mitophagy mediators. The compounds seem to upregulate mitophagy and thereby alleviate the clearance of dysfunctional and aged mitochondria as well as mitogenesis. Thus, the Mediterranean or Okinawan diet could represent a feasible nutritional approach to reduce the risk of developing age-related cognitive impairment and corresponding disorders via the stimulation of mitophagy and thereby ensure a balanced redox state of brain cells.
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spelling pubmed-76002822020-11-01 Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging? Varghese, Nimmy Werner, Selina Grimm, Amandine Eckert, Anne Antioxidants (Basel) Review Recently, nutritional interventions have received attention as promising approaches to promote human health during a lifespan. The Mediterranean and Okinawan diets have been associated with longevity and decreasing risk for age-related diseases in contrast to the Western diet. The effect might be due to several antioxidative bioactive compounds highly consumed in both diets, namely, resveratrol, hydroxytyrosol, oleuropein, curcumin, and spermidine. This review aims to address the underlying mechanisms of these compounds to enhance mental fitness throughout life with a focus on brain mitophagy. Mitophagy is the autophagic clearance of dysfunctional, redundant, and aged mitochondria. In aging and neurodegenerative disorders, mitophagy is crucial to preserve the autophagy mechanism of the whole cell, especially during oxidative stress. Growing evidence indicates that curcumin, astaxanthin, resveratrol, hydroxytyrosol, oleuropein, and spermidine might exert protective functions via antioxidative properties and as well the enhanced induction of mitophagy mediators. The compounds seem to upregulate mitophagy and thereby alleviate the clearance of dysfunctional and aged mitochondria as well as mitogenesis. Thus, the Mediterranean or Okinawan diet could represent a feasible nutritional approach to reduce the risk of developing age-related cognitive impairment and corresponding disorders via the stimulation of mitophagy and thereby ensure a balanced redox state of brain cells. MDPI 2020-09-29 /pmc/articles/PMC7600282/ /pubmed/33003315 http://dx.doi.org/10.3390/antiox9100932 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Varghese, Nimmy
Werner, Selina
Grimm, Amandine
Eckert, Anne
Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?
title Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?
title_full Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?
title_fullStr Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?
title_full_unstemmed Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?
title_short Dietary Mitophagy Enhancer: A Strategy for Healthy Brain Aging?
title_sort dietary mitophagy enhancer: a strategy for healthy brain aging?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600282/
https://www.ncbi.nlm.nih.gov/pubmed/33003315
http://dx.doi.org/10.3390/antiox9100932
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