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Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control

Vesicular nanocarriers have an important role in drug delivery and dietary supplements. Size control and optimization of encapsulation efficiency (EE) should be optimized for those applications. In this work, we report on the identification of the crucial step (injection, evaporation, or sonication)...

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Autores principales: Estupiñan, Oscar R., Garcia-Manrique, Pablo, Blanco-Lopez, Maria del Carmen, Matos, Maria, Gutiérrez, Gemma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600288/
https://www.ncbi.nlm.nih.gov/pubmed/32993064
http://dx.doi.org/10.3390/foods9101367
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author Estupiñan, Oscar R.
Garcia-Manrique, Pablo
Blanco-Lopez, Maria del Carmen
Matos, Maria
Gutiérrez, Gemma
author_facet Estupiñan, Oscar R.
Garcia-Manrique, Pablo
Blanco-Lopez, Maria del Carmen
Matos, Maria
Gutiérrez, Gemma
author_sort Estupiñan, Oscar R.
collection PubMed
description Vesicular nanocarriers have an important role in drug delivery and dietary supplements. Size control and optimization of encapsulation efficiency (EE) should be optimized for those applications. In this work, we report on the identification of the crucial step (injection, evaporation, or sonication) innanovesicles (transfersomes and niosomes) preparation by theethanol injection method (EI). The identification of each production step on the final vesicle size was analyzed in order to optimize further scale-up process. Results indicated that the final size of transfersomeswas clearly influenced by the sonication step while the final size of niosomes was mainly governed by the injection step. Measurements of final surface tension of the different vesicular systems prepared indicate a linear positive tendency with the vesicle size formed. This relation could help to better understand the process and design a vesicular size prediction model for EI. Vitamin D3 (VitD3) was encapsulated in the systems formulated with encapsulation efficiencies larger than 90%. Interaction between the encapsulated compound and the membrane layer components is crucial for vesicle stability. This work has an impact on the scaling-up production of vesicles for further food science applications.
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spelling pubmed-76002882020-11-01 Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control Estupiñan, Oscar R. Garcia-Manrique, Pablo Blanco-Lopez, Maria del Carmen Matos, Maria Gutiérrez, Gemma Foods Article Vesicular nanocarriers have an important role in drug delivery and dietary supplements. Size control and optimization of encapsulation efficiency (EE) should be optimized for those applications. In this work, we report on the identification of the crucial step (injection, evaporation, or sonication) innanovesicles (transfersomes and niosomes) preparation by theethanol injection method (EI). The identification of each production step on the final vesicle size was analyzed in order to optimize further scale-up process. Results indicated that the final size of transfersomeswas clearly influenced by the sonication step while the final size of niosomes was mainly governed by the injection step. Measurements of final surface tension of the different vesicular systems prepared indicate a linear positive tendency with the vesicle size formed. This relation could help to better understand the process and design a vesicular size prediction model for EI. Vitamin D3 (VitD3) was encapsulated in the systems formulated with encapsulation efficiencies larger than 90%. Interaction between the encapsulated compound and the membrane layer components is crucial for vesicle stability. This work has an impact on the scaling-up production of vesicles for further food science applications. MDPI 2020-09-26 /pmc/articles/PMC7600288/ /pubmed/32993064 http://dx.doi.org/10.3390/foods9101367 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Estupiñan, Oscar R.
Garcia-Manrique, Pablo
Blanco-Lopez, Maria del Carmen
Matos, Maria
Gutiérrez, Gemma
Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control
title Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control
title_full Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control
title_fullStr Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control
title_full_unstemmed Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control
title_short Vitamin D3 Loaded Niosomes and Transfersomes Produced by Ethanol Injection Method: Identification of the Critical Preparation Step for Size Control
title_sort vitamin d3 loaded niosomes and transfersomes produced by ethanol injection method: identification of the critical preparation step for size control
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600288/
https://www.ncbi.nlm.nih.gov/pubmed/32993064
http://dx.doi.org/10.3390/foods9101367
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