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Investigation of Brucella melitensis in Sable Antelope (Hippotragus niger) in South Africa
In this study, Brucella melitensis infection in sable antelope (Hippotragus niger) was investigated on two wildlife ranches in South Africa over a 12-year period in order to determine the origin of the outbreaks and the role of livestock in maintaining the disease. Retrospective data were obtained f...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600299/ https://www.ncbi.nlm.nih.gov/pubmed/33003292 http://dx.doi.org/10.3390/microorganisms8101494 |
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author | Glover, Barbara Macfarlane, Malcolm Bengis, Roy O’Dell, Jacques Steyl, Johan van Heerden, Henriette Abernethy, Darrell |
author_facet | Glover, Barbara Macfarlane, Malcolm Bengis, Roy O’Dell, Jacques Steyl, Johan van Heerden, Henriette Abernethy, Darrell |
author_sort | Glover, Barbara |
collection | PubMed |
description | In this study, Brucella melitensis infection in sable antelope (Hippotragus niger) was investigated on two wildlife ranches in South Africa over a 12-year period in order to determine the origin of the outbreaks and the role of livestock in maintaining the disease. Retrospective data were obtained from farm records and interviews as well as samples tested from different disease scenarios and clinical settings. On one ranch, 10 of 74 sable tested seropositive for B. melitensis in 2004 but were certified clear of infection after no further brucellosis cases were detected following repeated serological tests and culling over a five-year period. Recrudescence occurred in 2013 (7 of 187 brucellosis positives) and in 2014 (one positive), with persistent, latent infection being the most reasonable explanation. In a second case study, linked to the first one through a common vendor, 15 of 80 sable tested positive in 2016, some five years after the acquisition of the animals from a putative source. Brucella melitensis biovar 1 and/or 3 were isolated from each outbreak on both ranches. Both outbreaks resulted in substantial losses for the owners, arising from testing and culling and significant resource expenditure by the state. The study identified the diagnostic challenges for identifying and resolving disease outbreaks in wildlife, the persistence of B. melitensis in sable, the risks associated with animal movements, and the need for a wildlife-sensitive disease control scheme. Although the actual source of infection could not be identified, the investigation points away from local livestock as a source of ongoing infection while the persistent infection is consistent with the disease circulating within small, ranched populations and being spread through the keeping and trading of high-value animals. The implications of the study findings to disease control in wildlife are discussed. |
format | Online Article Text |
id | pubmed-7600299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76002992020-11-01 Investigation of Brucella melitensis in Sable Antelope (Hippotragus niger) in South Africa Glover, Barbara Macfarlane, Malcolm Bengis, Roy O’Dell, Jacques Steyl, Johan van Heerden, Henriette Abernethy, Darrell Microorganisms Article In this study, Brucella melitensis infection in sable antelope (Hippotragus niger) was investigated on two wildlife ranches in South Africa over a 12-year period in order to determine the origin of the outbreaks and the role of livestock in maintaining the disease. Retrospective data were obtained from farm records and interviews as well as samples tested from different disease scenarios and clinical settings. On one ranch, 10 of 74 sable tested seropositive for B. melitensis in 2004 but were certified clear of infection after no further brucellosis cases were detected following repeated serological tests and culling over a five-year period. Recrudescence occurred in 2013 (7 of 187 brucellosis positives) and in 2014 (one positive), with persistent, latent infection being the most reasonable explanation. In a second case study, linked to the first one through a common vendor, 15 of 80 sable tested positive in 2016, some five years after the acquisition of the animals from a putative source. Brucella melitensis biovar 1 and/or 3 were isolated from each outbreak on both ranches. Both outbreaks resulted in substantial losses for the owners, arising from testing and culling and significant resource expenditure by the state. The study identified the diagnostic challenges for identifying and resolving disease outbreaks in wildlife, the persistence of B. melitensis in sable, the risks associated with animal movements, and the need for a wildlife-sensitive disease control scheme. Although the actual source of infection could not be identified, the investigation points away from local livestock as a source of ongoing infection while the persistent infection is consistent with the disease circulating within small, ranched populations and being spread through the keeping and trading of high-value animals. The implications of the study findings to disease control in wildlife are discussed. MDPI 2020-09-29 /pmc/articles/PMC7600299/ /pubmed/33003292 http://dx.doi.org/10.3390/microorganisms8101494 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Glover, Barbara Macfarlane, Malcolm Bengis, Roy O’Dell, Jacques Steyl, Johan van Heerden, Henriette Abernethy, Darrell Investigation of Brucella melitensis in Sable Antelope (Hippotragus niger) in South Africa |
title | Investigation of Brucella melitensis in Sable Antelope (Hippotragus niger) in South Africa |
title_full | Investigation of Brucella melitensis in Sable Antelope (Hippotragus niger) in South Africa |
title_fullStr | Investigation of Brucella melitensis in Sable Antelope (Hippotragus niger) in South Africa |
title_full_unstemmed | Investigation of Brucella melitensis in Sable Antelope (Hippotragus niger) in South Africa |
title_short | Investigation of Brucella melitensis in Sable Antelope (Hippotragus niger) in South Africa |
title_sort | investigation of brucella melitensis in sable antelope (hippotragus niger) in south africa |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600299/ https://www.ncbi.nlm.nih.gov/pubmed/33003292 http://dx.doi.org/10.3390/microorganisms8101494 |
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