Prostate Cancer Metastases Are Strongly Inhibited by Agonistic Epha2 Ligands in an Orthotopic Mouse Model

SIMPLE SUMMARY: We demonstrate that pro-oncogenic EphA2 (ephrin type-A receptor 2) expression is activated in aggressive prostate cancers, and in mouse models of prostate cancers that are treated with enzalutamide. We also demonstrate in mouse models, that agonistic EphA2 targeting agents are very e...

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Detalles Bibliográficos
Autores principales: Salem, Ahmed F., Gambini, Luca, Billet, Sandrine, Sun, Yu, Oshiro, Hiromichi, Zhao, Ming, Hoffman, Robert M., Bhowmick, Neil A., Pellecchia, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600344/
https://www.ncbi.nlm.nih.gov/pubmed/33023262
http://dx.doi.org/10.3390/cancers12102854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600344/
https://www.ncbi.nlm.nih.gov/pubmed/33023262
http://dx.doi.org/10.3390/cancers12102854

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