Modulation of Guanylate Cyclase Activating Protein 1 (GCAP1) Dimeric Assembly by Ca(2+) or Mg(2+): Hints to Understand Protein Activity

The guanylyl cyclase-activating protein 1, GCAP1, activates or inhibits retinal guanylyl cyclase (retGC) depending on cellular Ca(2+) concentrations. Several point mutations of GCAP1 have been associated with impaired calcium sensitivity that eventually triggers progressive retinal degeneration. In...

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Detalles Bibliográficos
Autores principales: Bonì, Francesco, Marino, Valerio, Bidoia, Carlo, Mastrangelo, Eloise, Barbiroli, Alberto, Dell’Orco, Daniele, Milani, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600425/
https://www.ncbi.nlm.nih.gov/pubmed/33027977
http://dx.doi.org/10.3390/biom10101408

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