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Microbiota, Fiber, and NAFLD: Is There Any Connection?
Gut microbiota can contribute to the development and progression of non-alcoholic fatty liver disease (NAFLD). In fact, some specific changes of gut microbiota are observed in patients in what is called dysbiota. There has been a lot of investigation by using a variety of interventions, including di...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600472/ https://www.ncbi.nlm.nih.gov/pubmed/33053631 http://dx.doi.org/10.3390/nu12103100 |
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author | Pérez-Montes de Oca, Alejandra Julián, María Teresa Ramos, Analía Puig-Domingo, Manel Alonso, Nuria |
author_facet | Pérez-Montes de Oca, Alejandra Julián, María Teresa Ramos, Analía Puig-Domingo, Manel Alonso, Nuria |
author_sort | Pérez-Montes de Oca, Alejandra |
collection | PubMed |
description | Gut microbiota can contribute to the development and progression of non-alcoholic fatty liver disease (NAFLD). In fact, some specific changes of gut microbiota are observed in patients in what is called dysbiota. There has been a lot of investigation by using a variety of interventions, including diet, showing the possibility to modify components of gastrointestinal dysbiota towards healthy and multivariate microbiota to restore physiologic status. One of the main focuses has been dietary fiber (DF), in which most of its variants are prebiotics. The highest effective treatment for NAFLD is, so far, weight loss achieved by caloric restriction. DF supplementation with oligofructose facilitates weight loss, enhances the production of beneficial metabolites, decreases some pathogenic bacteria population by increasing Bifidobacteria, and has effects on intestinal barrier permeability. DF use has been associated with improvement in diverse metabolic diseases, including NAFLD, by modifying gut microbiota. Additionally, it has been shown that a higher insoluble fiber consumption (≥7.5 g/day) revealed improvements in 3 different scores of liver fibrosis. Further research is needed, but given the evidence available, it is reasonable to prescribe its consumption in early stages of NAFLD in order to prevent disease progression. |
format | Online Article Text |
id | pubmed-7600472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76004722020-11-01 Microbiota, Fiber, and NAFLD: Is There Any Connection? Pérez-Montes de Oca, Alejandra Julián, María Teresa Ramos, Analía Puig-Domingo, Manel Alonso, Nuria Nutrients Review Gut microbiota can contribute to the development and progression of non-alcoholic fatty liver disease (NAFLD). In fact, some specific changes of gut microbiota are observed in patients in what is called dysbiota. There has been a lot of investigation by using a variety of interventions, including diet, showing the possibility to modify components of gastrointestinal dysbiota towards healthy and multivariate microbiota to restore physiologic status. One of the main focuses has been dietary fiber (DF), in which most of its variants are prebiotics. The highest effective treatment for NAFLD is, so far, weight loss achieved by caloric restriction. DF supplementation with oligofructose facilitates weight loss, enhances the production of beneficial metabolites, decreases some pathogenic bacteria population by increasing Bifidobacteria, and has effects on intestinal barrier permeability. DF use has been associated with improvement in diverse metabolic diseases, including NAFLD, by modifying gut microbiota. Additionally, it has been shown that a higher insoluble fiber consumption (≥7.5 g/day) revealed improvements in 3 different scores of liver fibrosis. Further research is needed, but given the evidence available, it is reasonable to prescribe its consumption in early stages of NAFLD in order to prevent disease progression. MDPI 2020-10-12 /pmc/articles/PMC7600472/ /pubmed/33053631 http://dx.doi.org/10.3390/nu12103100 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pérez-Montes de Oca, Alejandra Julián, María Teresa Ramos, Analía Puig-Domingo, Manel Alonso, Nuria Microbiota, Fiber, and NAFLD: Is There Any Connection? |
title | Microbiota, Fiber, and NAFLD: Is There Any Connection? |
title_full | Microbiota, Fiber, and NAFLD: Is There Any Connection? |
title_fullStr | Microbiota, Fiber, and NAFLD: Is There Any Connection? |
title_full_unstemmed | Microbiota, Fiber, and NAFLD: Is There Any Connection? |
title_short | Microbiota, Fiber, and NAFLD: Is There Any Connection? |
title_sort | microbiota, fiber, and nafld: is there any connection? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600472/ https://www.ncbi.nlm.nih.gov/pubmed/33053631 http://dx.doi.org/10.3390/nu12103100 |
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