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Lysogeny in Streptococcus pneumoniae
Bacterial viruses, or bacteriophages, are major contributors to the evolution, pathogenesis and overall biology of their host bacteria. During their life cycle, temperate bacteriophages form stable associations with their host by integrating into the chromosome, a process called lysogeny. Isolates o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600539/ https://www.ncbi.nlm.nih.gov/pubmed/33036379 http://dx.doi.org/10.3390/microorganisms8101546 |
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author | Garriss, Geneviève Henriques-Normark, Birgitta |
author_facet | Garriss, Geneviève Henriques-Normark, Birgitta |
author_sort | Garriss, Geneviève |
collection | PubMed |
description | Bacterial viruses, or bacteriophages, are major contributors to the evolution, pathogenesis and overall biology of their host bacteria. During their life cycle, temperate bacteriophages form stable associations with their host by integrating into the chromosome, a process called lysogeny. Isolates of the human pathogen Streptococcus pneumoniae are frequently lysogenic, and genomic studies have allowed the classification of these phages into distinct phylogenetic groups. Here, we review the recent advances in the characterization of temperate pneumococcal phages, with a focus on their genetic features and chromosomal integration loci. We also discuss the contribution of phages, and specific phage-encoded features, to colonization and virulence. Finally, we discuss interesting research perspectives in this field. |
format | Online Article Text |
id | pubmed-7600539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76005392020-11-01 Lysogeny in Streptococcus pneumoniae Garriss, Geneviève Henriques-Normark, Birgitta Microorganisms Review Bacterial viruses, or bacteriophages, are major contributors to the evolution, pathogenesis and overall biology of their host bacteria. During their life cycle, temperate bacteriophages form stable associations with their host by integrating into the chromosome, a process called lysogeny. Isolates of the human pathogen Streptococcus pneumoniae are frequently lysogenic, and genomic studies have allowed the classification of these phages into distinct phylogenetic groups. Here, we review the recent advances in the characterization of temperate pneumococcal phages, with a focus on their genetic features and chromosomal integration loci. We also discuss the contribution of phages, and specific phage-encoded features, to colonization and virulence. Finally, we discuss interesting research perspectives in this field. MDPI 2020-10-07 /pmc/articles/PMC7600539/ /pubmed/33036379 http://dx.doi.org/10.3390/microorganisms8101546 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Garriss, Geneviève Henriques-Normark, Birgitta Lysogeny in Streptococcus pneumoniae |
title | Lysogeny in Streptococcus pneumoniae |
title_full | Lysogeny in Streptococcus pneumoniae |
title_fullStr | Lysogeny in Streptococcus pneumoniae |
title_full_unstemmed | Lysogeny in Streptococcus pneumoniae |
title_short | Lysogeny in Streptococcus pneumoniae |
title_sort | lysogeny in streptococcus pneumoniae |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600539/ https://www.ncbi.nlm.nih.gov/pubmed/33036379 http://dx.doi.org/10.3390/microorganisms8101546 |
work_keys_str_mv | AT garrissgenevieve lysogenyinstreptococcuspneumoniae AT henriquesnormarkbirgitta lysogenyinstreptococcuspneumoniae |