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The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)

There is a deep need for mortality predictors that allow clinicians to quickly triage patients with severe coronavirus disease 2019 (Covid-19) into intensive care units at the time of hospital admission. Thus, we examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-mon...

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Autores principales: Rizo-Téllez, Salma A., Méndez-García, Lucia A., Flores-Rebollo, Cruz, Alba-Flores, Fernando, Alcántara-Suárez, Raúl, Manjarrez-Reyna, Aarón N., Baltazar-López, Neyla, Hernández-Guzmán, Verónica A., León-Pedroza, José I., Zapata-Arenas, Rogelio, González-Chávez, Antonio, Hernández-Ruíz, Joselín, Carrillo-Ruíz, José D., Serrano-Loyola, Raúl, Guerrero-Avendaño, Guadalupe M. L., Escobedo, Galileo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600553/
https://www.ncbi.nlm.nih.gov/pubmed/33050487
http://dx.doi.org/10.3390/microorganisms8101560
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author Rizo-Téllez, Salma A.
Méndez-García, Lucia A.
Flores-Rebollo, Cruz
Alba-Flores, Fernando
Alcántara-Suárez, Raúl
Manjarrez-Reyna, Aarón N.
Baltazar-López, Neyla
Hernández-Guzmán, Verónica A.
León-Pedroza, José I.
Zapata-Arenas, Rogelio
González-Chávez, Antonio
Hernández-Ruíz, Joselín
Carrillo-Ruíz, José D.
Serrano-Loyola, Raúl
Guerrero-Avendaño, Guadalupe M. L.
Escobedo, Galileo
author_facet Rizo-Téllez, Salma A.
Méndez-García, Lucia A.
Flores-Rebollo, Cruz
Alba-Flores, Fernando
Alcántara-Suárez, Raúl
Manjarrez-Reyna, Aarón N.
Baltazar-López, Neyla
Hernández-Guzmán, Verónica A.
León-Pedroza, José I.
Zapata-Arenas, Rogelio
González-Chávez, Antonio
Hernández-Ruíz, Joselín
Carrillo-Ruíz, José D.
Serrano-Loyola, Raúl
Guerrero-Avendaño, Guadalupe M. L.
Escobedo, Galileo
author_sort Rizo-Téllez, Salma A.
collection PubMed
description There is a deep need for mortality predictors that allow clinicians to quickly triage patients with severe coronavirus disease 2019 (Covid-19) into intensive care units at the time of hospital admission. Thus, we examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-monocyte ratio (NMR) as predictors of in-hospital death at admission in patients with severe Covid-19. A total of 54 Mexican adult patients with Covid-19 that met hospitalization criteria were retrospectively enrolled, followed-up daily until hospital discharge or death, and then assigned to survival or non-survival groups. Clinical, demographic, and laboratory parameters were recorded at admission. A total of 20 patients with severe Covid-19 died, and 75% of them were men older than 62.90 ± 14.18 years on average. Type 2 diabetes, hypertension, and coronary heart disease were more prevalent in non-survivors. As compared to survivors, LNR was significantly fourfold decreased while NMR was twofold increased. LNR ≤ 0.088 predicted in-hospital mortality with a sensitivity of 85.00% and a specificity of 74.19%. NMR ≥ 17.75 was a better independent risk factor for mortality with a sensitivity of 89.47% and a specificity of 80.00%. This study demonstrates for the first time that NMR and LNR are accurate predictors of in-hospital mortality at admission in patients with severe Covid-19.
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spelling pubmed-76005532020-11-01 The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19) Rizo-Téllez, Salma A. Méndez-García, Lucia A. Flores-Rebollo, Cruz Alba-Flores, Fernando Alcántara-Suárez, Raúl Manjarrez-Reyna, Aarón N. Baltazar-López, Neyla Hernández-Guzmán, Verónica A. León-Pedroza, José I. Zapata-Arenas, Rogelio González-Chávez, Antonio Hernández-Ruíz, Joselín Carrillo-Ruíz, José D. Serrano-Loyola, Raúl Guerrero-Avendaño, Guadalupe M. L. Escobedo, Galileo Microorganisms Article There is a deep need for mortality predictors that allow clinicians to quickly triage patients with severe coronavirus disease 2019 (Covid-19) into intensive care units at the time of hospital admission. Thus, we examined the efficacy of the lymphocyte-to-neutrophil ratio (LNR) and neutrophil-to-monocyte ratio (NMR) as predictors of in-hospital death at admission in patients with severe Covid-19. A total of 54 Mexican adult patients with Covid-19 that met hospitalization criteria were retrospectively enrolled, followed-up daily until hospital discharge or death, and then assigned to survival or non-survival groups. Clinical, demographic, and laboratory parameters were recorded at admission. A total of 20 patients with severe Covid-19 died, and 75% of them were men older than 62.90 ± 14.18 years on average. Type 2 diabetes, hypertension, and coronary heart disease were more prevalent in non-survivors. As compared to survivors, LNR was significantly fourfold decreased while NMR was twofold increased. LNR ≤ 0.088 predicted in-hospital mortality with a sensitivity of 85.00% and a specificity of 74.19%. NMR ≥ 17.75 was a better independent risk factor for mortality with a sensitivity of 89.47% and a specificity of 80.00%. This study demonstrates for the first time that NMR and LNR are accurate predictors of in-hospital mortality at admission in patients with severe Covid-19. MDPI 2020-10-10 /pmc/articles/PMC7600553/ /pubmed/33050487 http://dx.doi.org/10.3390/microorganisms8101560 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rizo-Téllez, Salma A.
Méndez-García, Lucia A.
Flores-Rebollo, Cruz
Alba-Flores, Fernando
Alcántara-Suárez, Raúl
Manjarrez-Reyna, Aarón N.
Baltazar-López, Neyla
Hernández-Guzmán, Verónica A.
León-Pedroza, José I.
Zapata-Arenas, Rogelio
González-Chávez, Antonio
Hernández-Ruíz, Joselín
Carrillo-Ruíz, José D.
Serrano-Loyola, Raúl
Guerrero-Avendaño, Guadalupe M. L.
Escobedo, Galileo
The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)
title The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)
title_full The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)
title_fullStr The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)
title_full_unstemmed The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)
title_short The Neutrophil-to-Monocyte Ratio and Lymphocyte-to-Neutrophil Ratio at Admission Predict In-Hospital Mortality in Mexican Patients with Severe SARS-CoV-2 Infection (Covid-19)
title_sort neutrophil-to-monocyte ratio and lymphocyte-to-neutrophil ratio at admission predict in-hospital mortality in mexican patients with severe sars-cov-2 infection (covid-19)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600553/
https://www.ncbi.nlm.nih.gov/pubmed/33050487
http://dx.doi.org/10.3390/microorganisms8101560
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