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Adaptation of Proteasomes and Lysosomes to Cellular Environments
Protein degradation is important for proper cellular physiology as it removes malfunctioning proteins or can provide a source for energy. Proteasomes and lysosomes, through the regulatory particles or adaptor proteins, respectively, recognize proteins destined for degradation. These systems have dev...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600607/ https://www.ncbi.nlm.nih.gov/pubmed/33019542 http://dx.doi.org/10.3390/cells9102221 |
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author | Mebratu, Yohannes Afework Negasi, Zerihun Hailemariam Dutta, Saugata Rojas-Quintero, Joselyn Tesfaigzi, Yohannes |
author_facet | Mebratu, Yohannes Afework Negasi, Zerihun Hailemariam Dutta, Saugata Rojas-Quintero, Joselyn Tesfaigzi, Yohannes |
author_sort | Mebratu, Yohannes Afework |
collection | PubMed |
description | Protein degradation is important for proper cellular physiology as it removes malfunctioning proteins or can provide a source for energy. Proteasomes and lysosomes, through the regulatory particles or adaptor proteins, respectively, recognize proteins destined for degradation. These systems have developed mechanisms to allow adaptation to the everchanging environment of the cell. While the complex recognition of proteins to be degraded is somewhat understood, the mechanisms that help switch the proteasomal regulatory particles or lysosomal adaptor proteins to adjust to the changing landscape of degrons, during infections or inflammation, still need extensive exploration. Therefore, this review is focused on describing the protein degradation systems and the possible sensors that may trigger the rapid adaptation of the protein degradation machinery. |
format | Online Article Text |
id | pubmed-7600607 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76006072020-11-01 Adaptation of Proteasomes and Lysosomes to Cellular Environments Mebratu, Yohannes Afework Negasi, Zerihun Hailemariam Dutta, Saugata Rojas-Quintero, Joselyn Tesfaigzi, Yohannes Cells Review Protein degradation is important for proper cellular physiology as it removes malfunctioning proteins or can provide a source for energy. Proteasomes and lysosomes, through the regulatory particles or adaptor proteins, respectively, recognize proteins destined for degradation. These systems have developed mechanisms to allow adaptation to the everchanging environment of the cell. While the complex recognition of proteins to be degraded is somewhat understood, the mechanisms that help switch the proteasomal regulatory particles or lysosomal adaptor proteins to adjust to the changing landscape of degrons, during infections or inflammation, still need extensive exploration. Therefore, this review is focused on describing the protein degradation systems and the possible sensors that may trigger the rapid adaptation of the protein degradation machinery. MDPI 2020-10-01 /pmc/articles/PMC7600607/ /pubmed/33019542 http://dx.doi.org/10.3390/cells9102221 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mebratu, Yohannes Afework Negasi, Zerihun Hailemariam Dutta, Saugata Rojas-Quintero, Joselyn Tesfaigzi, Yohannes Adaptation of Proteasomes and Lysosomes to Cellular Environments |
title | Adaptation of Proteasomes and Lysosomes to Cellular Environments |
title_full | Adaptation of Proteasomes and Lysosomes to Cellular Environments |
title_fullStr | Adaptation of Proteasomes and Lysosomes to Cellular Environments |
title_full_unstemmed | Adaptation of Proteasomes and Lysosomes to Cellular Environments |
title_short | Adaptation of Proteasomes and Lysosomes to Cellular Environments |
title_sort | adaptation of proteasomes and lysosomes to cellular environments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600607/ https://www.ncbi.nlm.nih.gov/pubmed/33019542 http://dx.doi.org/10.3390/cells9102221 |
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