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Lab-on-a-Chip for Cardiovascular Physiology and Pathology

Lab-on-a-chip technologies have allowed researchers to acquire a flexible, yet relatively inexpensive testbed to study one of the leading causes of death worldwide, cardiovascular disease. Cardiovascular diseases, such as peripheral artery disease, arteriosclerosis, and aortic stenosis, for example,...

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Detalles Bibliográficos
Autores principales: Beverung, Sean, Wu, Jingwen, Steward, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600691/
https://www.ncbi.nlm.nih.gov/pubmed/32998305
http://dx.doi.org/10.3390/mi11100898
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author Beverung, Sean
Wu, Jingwen
Steward, Robert
author_facet Beverung, Sean
Wu, Jingwen
Steward, Robert
author_sort Beverung, Sean
collection PubMed
description Lab-on-a-chip technologies have allowed researchers to acquire a flexible, yet relatively inexpensive testbed to study one of the leading causes of death worldwide, cardiovascular disease. Cardiovascular diseases, such as peripheral artery disease, arteriosclerosis, and aortic stenosis, for example, have all been studied by lab-on-a-chip technologies. These technologies allow for the integration of mammalian cells into functional structures that mimic vital organs with geometries comparable to those found in vivo. For this review, we focus on microdevices that have been developed to study cardiovascular physiology and pathology. With these technologies, researchers can better understand the electrical–biomechanical properties unique to cardiomyocytes and better stimulate and understand the influence of blood flow on the human vasculature. Such studies have helped increase our understanding of many cardiovascular diseases in general; as such, we present here a review of the current state of the field and potential for the future.
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spelling pubmed-76006912020-11-01 Lab-on-a-Chip for Cardiovascular Physiology and Pathology Beverung, Sean Wu, Jingwen Steward, Robert Micromachines (Basel) Review Lab-on-a-chip technologies have allowed researchers to acquire a flexible, yet relatively inexpensive testbed to study one of the leading causes of death worldwide, cardiovascular disease. Cardiovascular diseases, such as peripheral artery disease, arteriosclerosis, and aortic stenosis, for example, have all been studied by lab-on-a-chip technologies. These technologies allow for the integration of mammalian cells into functional structures that mimic vital organs with geometries comparable to those found in vivo. For this review, we focus on microdevices that have been developed to study cardiovascular physiology and pathology. With these technologies, researchers can better understand the electrical–biomechanical properties unique to cardiomyocytes and better stimulate and understand the influence of blood flow on the human vasculature. Such studies have helped increase our understanding of many cardiovascular diseases in general; as such, we present here a review of the current state of the field and potential for the future. MDPI 2020-09-28 /pmc/articles/PMC7600691/ /pubmed/32998305 http://dx.doi.org/10.3390/mi11100898 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Beverung, Sean
Wu, Jingwen
Steward, Robert
Lab-on-a-Chip for Cardiovascular Physiology and Pathology
title Lab-on-a-Chip for Cardiovascular Physiology and Pathology
title_full Lab-on-a-Chip for Cardiovascular Physiology and Pathology
title_fullStr Lab-on-a-Chip for Cardiovascular Physiology and Pathology
title_full_unstemmed Lab-on-a-Chip for Cardiovascular Physiology and Pathology
title_short Lab-on-a-Chip for Cardiovascular Physiology and Pathology
title_sort lab-on-a-chip for cardiovascular physiology and pathology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600691/
https://www.ncbi.nlm.nih.gov/pubmed/32998305
http://dx.doi.org/10.3390/mi11100898
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