Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9

The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated by antiretroviral therapy. The “shock and kill” approach entails stimulating viral production with latency-reversing agents followed by the killing of cells actively producing the virus by immune clearance...

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Detalles Bibliográficos
Autores principales: Olson, Alex, Basukala, Binita, Lee, Seunghee, Gagne, Matthew, Wong, Wilson W., Henderson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600714/
https://www.ncbi.nlm.nih.gov/pubmed/33053801
http://dx.doi.org/10.3390/v12101154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600714/
https://www.ncbi.nlm.nih.gov/pubmed/33053801
http://dx.doi.org/10.3390/v12101154

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