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Targeted Chromatinization and Repression of HIV-1 Provirus Transcription with Repurposed CRISPR/Cas9
The major barrier to HIV-1 cure is the persistence of latent provirus, which is not eradicated by antiretroviral therapy. The “shock and kill” approach entails stimulating viral production with latency-reversing agents followed by the killing of cells actively producing the virus by immune clearance...
Autores principales: | Olson, Alex, Basukala, Binita, Lee, Seunghee, Gagne, Matthew, Wong, Wilson W., Henderson, Andrew J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600714/ https://www.ncbi.nlm.nih.gov/pubmed/33053801 http://dx.doi.org/10.3390/v12101154 |
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