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Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo

Dietary supplementation based on sea buckthorn and rosehip oils with added chokeberry extract was studied. We added the dietary supplement to the feed mixtures for laboratory animals. The possible toxicological effects and hypocholesterolemic, hepatoprotective activity of the dietary supplement in v...

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Autores principales: Tereshchuk, Lubov, Starovoytova, Kseniya, Babich, Olga, Dyshlyuk, Lyubov, Sergeeva, Irina, Pavsky, Valery, Ivanova, Svetlana, Prosekov, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600764/
https://www.ncbi.nlm.nih.gov/pubmed/32992796
http://dx.doi.org/10.3390/nu12102941
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author Tereshchuk, Lubov
Starovoytova, Kseniya
Babich, Olga
Dyshlyuk, Lyubov
Sergeeva, Irina
Pavsky, Valery
Ivanova, Svetlana
Prosekov, Alexander
author_facet Tereshchuk, Lubov
Starovoytova, Kseniya
Babich, Olga
Dyshlyuk, Lyubov
Sergeeva, Irina
Pavsky, Valery
Ivanova, Svetlana
Prosekov, Alexander
author_sort Tereshchuk, Lubov
collection PubMed
description Dietary supplementation based on sea buckthorn and rosehip oils with added chokeberry extract was studied. We added the dietary supplement to the feed mixtures for laboratory animals. The possible toxicological effects and hypocholesterolemic, hepatoprotective activity of the dietary supplement in vivo were studied. After the observation period (6 weeks), no significant changes were found in the mass of organs and blood serum of laboratory animals (p > 0.05). However, there was a decrease in hypercholesterolemic indicators. Regular consumption of sea buckthorn and rosehip oils with added chokeberry extract (dietary supplement “ESB-1”) by laboratory animals inhibited the activity of liver enzymes and increased the antioxidant activity of blood serum (after the subcutaneous injection of sunflower oil/oil solution of carbon tetrachloride) but was not sufficient to bring them to physiological standards. The hypocholesterolemic and antioxidant properties of our dietary supplement already allow us to consider it a component of functional food products or a dietary supplement base. However, the full range of its biologically active properties, including the hepatoprotective function and regulation of metabolic disorders, has not been studied yet, which sets the direction of further research in vivo models and clinical practice to confirm its effectiveness in humans.
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spelling pubmed-76007642020-11-01 Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo Tereshchuk, Lubov Starovoytova, Kseniya Babich, Olga Dyshlyuk, Lyubov Sergeeva, Irina Pavsky, Valery Ivanova, Svetlana Prosekov, Alexander Nutrients Article Dietary supplementation based on sea buckthorn and rosehip oils with added chokeberry extract was studied. We added the dietary supplement to the feed mixtures for laboratory animals. The possible toxicological effects and hypocholesterolemic, hepatoprotective activity of the dietary supplement in vivo were studied. After the observation period (6 weeks), no significant changes were found in the mass of organs and blood serum of laboratory animals (p > 0.05). However, there was a decrease in hypercholesterolemic indicators. Regular consumption of sea buckthorn and rosehip oils with added chokeberry extract (dietary supplement “ESB-1”) by laboratory animals inhibited the activity of liver enzymes and increased the antioxidant activity of blood serum (after the subcutaneous injection of sunflower oil/oil solution of carbon tetrachloride) but was not sufficient to bring them to physiological standards. The hypocholesterolemic and antioxidant properties of our dietary supplement already allow us to consider it a component of functional food products or a dietary supplement base. However, the full range of its biologically active properties, including the hepatoprotective function and regulation of metabolic disorders, has not been studied yet, which sets the direction of further research in vivo models and clinical practice to confirm its effectiveness in humans. MDPI 2020-09-25 /pmc/articles/PMC7600764/ /pubmed/32992796 http://dx.doi.org/10.3390/nu12102941 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tereshchuk, Lubov
Starovoytova, Kseniya
Babich, Olga
Dyshlyuk, Lyubov
Sergeeva, Irina
Pavsky, Valery
Ivanova, Svetlana
Prosekov, Alexander
Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo
title Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo
title_full Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo
title_fullStr Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo
title_full_unstemmed Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo
title_short Sea Buckthorn and Rosehip Oils with Chokeberry Extract to Prevent Hypercholesterolemia in Mice Caused by a High-Fat Diet In Vivo
title_sort sea buckthorn and rosehip oils with chokeberry extract to prevent hypercholesterolemia in mice caused by a high-fat diet in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600764/
https://www.ncbi.nlm.nih.gov/pubmed/32992796
http://dx.doi.org/10.3390/nu12102941
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