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Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease
To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A to...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600792/ https://www.ncbi.nlm.nih.gov/pubmed/32992530 http://dx.doi.org/10.3390/jcm9103121 |
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author | Lee, Hak Seung Park, Kyung Woo Kang, Jeehoon Ki, You-Jeong Chang, Mineok Han, Jung-Kyu Yang, Han-Mo Kang, Hyun-Jae Koo, Bon-Kwon Kim, Hyo-Soo |
author_facet | Lee, Hak Seung Park, Kyung Woo Kang, Jeehoon Ki, You-Jeong Chang, Mineok Han, Jung-Kyu Yang, Han-Mo Kang, Hyun-Jae Koo, Bon-Kwon Kim, Hyo-Soo |
author_sort | Lee, Hak Seung |
collection | PubMed |
description | To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A total of 1086 older patients (65 years or older) who underwent PCI with second-generation drug-eluting stents (DES) were enrolled. The total population was divided into quartiles according to the SI, stratified by sex. The primary clinical outcomes were major adverse cardiovascular events (MACE, all-cause death, myocardial infarction and target lesion revascularization) and thrombolysis in myocardial infarction major and minor bleeding during a 3-year follow-up period. In the total population, MACE occurred within 3 years in 154 (14.2%) patients. The lowest SI quartile group (Q1) had a significantly higher 3-year MACE rate (Q1 vs. Q2–4; 23.1% vs. 11.2%, p < 0.001), while bleeding event rates were similar between the groups (Q1 vs. Q2–4; 2.6% vs. 2.2%, p = 0.656). The Cox proportional hazard model showed that lower SI is an independent predictor for MACE events (HR 2.23, 95% CI 1.62–3.07, p < 0.001). The SI, a surrogate for the degree of muscle mass, is associated with cardiovascular and non-cardiovascular death, but not with bleeding in older patients who underwent PCI. |
format | Online Article Text |
id | pubmed-7600792 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76007922020-11-01 Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease Lee, Hak Seung Park, Kyung Woo Kang, Jeehoon Ki, You-Jeong Chang, Mineok Han, Jung-Kyu Yang, Han-Mo Kang, Hyun-Jae Koo, Bon-Kwon Kim, Hyo-Soo J Clin Med Article To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A total of 1086 older patients (65 years or older) who underwent PCI with second-generation drug-eluting stents (DES) were enrolled. The total population was divided into quartiles according to the SI, stratified by sex. The primary clinical outcomes were major adverse cardiovascular events (MACE, all-cause death, myocardial infarction and target lesion revascularization) and thrombolysis in myocardial infarction major and minor bleeding during a 3-year follow-up period. In the total population, MACE occurred within 3 years in 154 (14.2%) patients. The lowest SI quartile group (Q1) had a significantly higher 3-year MACE rate (Q1 vs. Q2–4; 23.1% vs. 11.2%, p < 0.001), while bleeding event rates were similar between the groups (Q1 vs. Q2–4; 2.6% vs. 2.2%, p = 0.656). The Cox proportional hazard model showed that lower SI is an independent predictor for MACE events (HR 2.23, 95% CI 1.62–3.07, p < 0.001). The SI, a surrogate for the degree of muscle mass, is associated with cardiovascular and non-cardiovascular death, but not with bleeding in older patients who underwent PCI. MDPI 2020-09-27 /pmc/articles/PMC7600792/ /pubmed/32992530 http://dx.doi.org/10.3390/jcm9103121 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Hak Seung Park, Kyung Woo Kang, Jeehoon Ki, You-Jeong Chang, Mineok Han, Jung-Kyu Yang, Han-Mo Kang, Hyun-Jae Koo, Bon-Kwon Kim, Hyo-Soo Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease |
title | Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease |
title_full | Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease |
title_fullStr | Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease |
title_full_unstemmed | Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease |
title_short | Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease |
title_sort | sarcopenia index as a predictor of clinical outcomes in older patients with coronary artery disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600792/ https://www.ncbi.nlm.nih.gov/pubmed/32992530 http://dx.doi.org/10.3390/jcm9103121 |
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