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Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease

To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A to...

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Autores principales: Lee, Hak Seung, Park, Kyung Woo, Kang, Jeehoon, Ki, You-Jeong, Chang, Mineok, Han, Jung-Kyu, Yang, Han-Mo, Kang, Hyun-Jae, Koo, Bon-Kwon, Kim, Hyo-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600792/
https://www.ncbi.nlm.nih.gov/pubmed/32992530
http://dx.doi.org/10.3390/jcm9103121
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author Lee, Hak Seung
Park, Kyung Woo
Kang, Jeehoon
Ki, You-Jeong
Chang, Mineok
Han, Jung-Kyu
Yang, Han-Mo
Kang, Hyun-Jae
Koo, Bon-Kwon
Kim, Hyo-Soo
author_facet Lee, Hak Seung
Park, Kyung Woo
Kang, Jeehoon
Ki, You-Jeong
Chang, Mineok
Han, Jung-Kyu
Yang, Han-Mo
Kang, Hyun-Jae
Koo, Bon-Kwon
Kim, Hyo-Soo
author_sort Lee, Hak Seung
collection PubMed
description To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A total of 1086 older patients (65 years or older) who underwent PCI with second-generation drug-eluting stents (DES) were enrolled. The total population was divided into quartiles according to the SI, stratified by sex. The primary clinical outcomes were major adverse cardiovascular events (MACE, all-cause death, myocardial infarction and target lesion revascularization) and thrombolysis in myocardial infarction major and minor bleeding during a 3-year follow-up period. In the total population, MACE occurred within 3 years in 154 (14.2%) patients. The lowest SI quartile group (Q1) had a significantly higher 3-year MACE rate (Q1 vs. Q2–4; 23.1% vs. 11.2%, p < 0.001), while bleeding event rates were similar between the groups (Q1 vs. Q2–4; 2.6% vs. 2.2%, p = 0.656). The Cox proportional hazard model showed that lower SI is an independent predictor for MACE events (HR 2.23, 95% CI 1.62–3.07, p < 0.001). The SI, a surrogate for the degree of muscle mass, is associated with cardiovascular and non-cardiovascular death, but not with bleeding in older patients who underwent PCI.
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spelling pubmed-76007922020-11-01 Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease Lee, Hak Seung Park, Kyung Woo Kang, Jeehoon Ki, You-Jeong Chang, Mineok Han, Jung-Kyu Yang, Han-Mo Kang, Hyun-Jae Koo, Bon-Kwon Kim, Hyo-Soo J Clin Med Article To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A total of 1086 older patients (65 years or older) who underwent PCI with second-generation drug-eluting stents (DES) were enrolled. The total population was divided into quartiles according to the SI, stratified by sex. The primary clinical outcomes were major adverse cardiovascular events (MACE, all-cause death, myocardial infarction and target lesion revascularization) and thrombolysis in myocardial infarction major and minor bleeding during a 3-year follow-up period. In the total population, MACE occurred within 3 years in 154 (14.2%) patients. The lowest SI quartile group (Q1) had a significantly higher 3-year MACE rate (Q1 vs. Q2–4; 23.1% vs. 11.2%, p < 0.001), while bleeding event rates were similar between the groups (Q1 vs. Q2–4; 2.6% vs. 2.2%, p = 0.656). The Cox proportional hazard model showed that lower SI is an independent predictor for MACE events (HR 2.23, 95% CI 1.62–3.07, p < 0.001). The SI, a surrogate for the degree of muscle mass, is associated with cardiovascular and non-cardiovascular death, but not with bleeding in older patients who underwent PCI. MDPI 2020-09-27 /pmc/articles/PMC7600792/ /pubmed/32992530 http://dx.doi.org/10.3390/jcm9103121 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Hak Seung
Park, Kyung Woo
Kang, Jeehoon
Ki, You-Jeong
Chang, Mineok
Han, Jung-Kyu
Yang, Han-Mo
Kang, Hyun-Jae
Koo, Bon-Kwon
Kim, Hyo-Soo
Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease
title Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease
title_full Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease
title_fullStr Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease
title_full_unstemmed Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease
title_short Sarcopenia Index as a Predictor of Clinical Outcomes in Older Patients with Coronary Artery Disease
title_sort sarcopenia index as a predictor of clinical outcomes in older patients with coronary artery disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600792/
https://www.ncbi.nlm.nih.gov/pubmed/32992530
http://dx.doi.org/10.3390/jcm9103121
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