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Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France

Describing the characteristics of COVID-19 patients in the hospital is of importance to assist in the management of hospital capacity in the future. Here, we analyze the trajectories of 1321 patients admitted to hospitals in northern and eastern France. We found that the time from onset to hospitali...

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Autores principales: Boëlle, Pierre-Yves, Delory, Tristan, Maynadier, Xavier, Janssen, Cécile, Piarroux, Renaud, Pichenot, Marie, Lemaire, Xavier, Baclet, Nicolas, Weyrich, Pierre, Melliez, Hugues, Meybeck, Agnès, Lanoix, Jean-Philippe, Robineau, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600846/
https://www.ncbi.nlm.nih.gov/pubmed/33003375
http://dx.doi.org/10.3390/jcm9103148
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author Boëlle, Pierre-Yves
Delory, Tristan
Maynadier, Xavier
Janssen, Cécile
Piarroux, Renaud
Pichenot, Marie
Lemaire, Xavier
Baclet, Nicolas
Weyrich, Pierre
Melliez, Hugues
Meybeck, Agnès
Lanoix, Jean-Philippe
Robineau, Olivier
author_facet Boëlle, Pierre-Yves
Delory, Tristan
Maynadier, Xavier
Janssen, Cécile
Piarroux, Renaud
Pichenot, Marie
Lemaire, Xavier
Baclet, Nicolas
Weyrich, Pierre
Melliez, Hugues
Meybeck, Agnès
Lanoix, Jean-Philippe
Robineau, Olivier
author_sort Boëlle, Pierre-Yves
collection PubMed
description Describing the characteristics of COVID-19 patients in the hospital is of importance to assist in the management of hospital capacity in the future. Here, we analyze the trajectories of 1321 patients admitted to hospitals in northern and eastern France. We found that the time from onset to hospitalization decreased with age, from 7.3 days in the 20–65 year-olds to 4.5 in the >80 year-olds (p < 0.0001). Overall, the length of stay in the hospital was 15.9 days, and the death rate was 20%. One patient out of four was admitted to the intensive care unit (ICU) for approximately one month. The characteristics of trajectories changed with age: fewer older patients were admitted to the ICU and the death rate was larger in the elderly. Admission shortly after onset was associated with increased mortality (odds-ratio (OR) = 1.8, Confidence Interval (CI) 95% [1.3, 2.6]) as well as male sex (OR = 2.1, CI 95% [1.5, 2.9]). Time from admission within the hospital to the transfer to ICU was short. The age- and sex-adjusted mortality rate decreased over the course of the epidemic, suggesting improvement in care over time. In the SARS-CoV-2 epidemic, the urgent need for ICU at admission and the prolonged length of stay in ICU are a challenge for bed management and organization of care.
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spelling pubmed-76008462020-11-01 Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France Boëlle, Pierre-Yves Delory, Tristan Maynadier, Xavier Janssen, Cécile Piarroux, Renaud Pichenot, Marie Lemaire, Xavier Baclet, Nicolas Weyrich, Pierre Melliez, Hugues Meybeck, Agnès Lanoix, Jean-Philippe Robineau, Olivier J Clin Med Article Describing the characteristics of COVID-19 patients in the hospital is of importance to assist in the management of hospital capacity in the future. Here, we analyze the trajectories of 1321 patients admitted to hospitals in northern and eastern France. We found that the time from onset to hospitalization decreased with age, from 7.3 days in the 20–65 year-olds to 4.5 in the >80 year-olds (p < 0.0001). Overall, the length of stay in the hospital was 15.9 days, and the death rate was 20%. One patient out of four was admitted to the intensive care unit (ICU) for approximately one month. The characteristics of trajectories changed with age: fewer older patients were admitted to the ICU and the death rate was larger in the elderly. Admission shortly after onset was associated with increased mortality (odds-ratio (OR) = 1.8, Confidence Interval (CI) 95% [1.3, 2.6]) as well as male sex (OR = 2.1, CI 95% [1.5, 2.9]). Time from admission within the hospital to the transfer to ICU was short. The age- and sex-adjusted mortality rate decreased over the course of the epidemic, suggesting improvement in care over time. In the SARS-CoV-2 epidemic, the urgent need for ICU at admission and the prolonged length of stay in ICU are a challenge for bed management and organization of care. MDPI 2020-09-29 /pmc/articles/PMC7600846/ /pubmed/33003375 http://dx.doi.org/10.3390/jcm9103148 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boëlle, Pierre-Yves
Delory, Tristan
Maynadier, Xavier
Janssen, Cécile
Piarroux, Renaud
Pichenot, Marie
Lemaire, Xavier
Baclet, Nicolas
Weyrich, Pierre
Melliez, Hugues
Meybeck, Agnès
Lanoix, Jean-Philippe
Robineau, Olivier
Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France
title Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France
title_full Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France
title_fullStr Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France
title_full_unstemmed Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France
title_short Trajectories of Hospitalization in COVID-19 Patients: An Observational Study in France
title_sort trajectories of hospitalization in covid-19 patients: an observational study in france
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600846/
https://www.ncbi.nlm.nih.gov/pubmed/33003375
http://dx.doi.org/10.3390/jcm9103148
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