Cargando…

IL-12 and IL-23—Close Relatives with Structural Homologies but Distinct Immunological Functions

Cytokines of the IL-12 family show structural similarities but have distinct functions in the immune system. Prominent members of this cytokine family are the pro-inflammatory cytokines IL-12 and IL-23. These two cytokines share cytokine subunits and receptor chains but have different functions in a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Floss, Doreen M., Moll, Jens M., Scheller, Jürgen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600943/ https://www.ncbi.nlm.nih.gov/pubmed/32998371 http://dx.doi.org/10.3390/cells9102184

Ejemplares similares

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction
por: Georgy, Jacqueline, et al.
Publicado: (2021)

Bispecific soluble cytokine receptor-nanobody fusions inhibit Interleukin (IL-)6 trans-signaling and IL-12/23 or tumor necrosis factor (TNF) signaling
por: Gesiorowski, Annika, et al.
Publicado: (2023)

Exclusive inhibition of IL-6 trans-signaling by soluble gp130(FlyR)Fc
por: Berg, Anna F., et al.
Publicado: (2021)

IL-23R Signaling Plays No Role in Myocardial Infarction
por: Engelowski, Erika, et al.
Publicado: (2018)

Cytokimera GIL-11 rescued IL-6R deficient mice from partial hepatectomy-induced death by signaling via non-natural gp130:LIFR:IL-11R complexes
por: Rafii, Puyan, et al.
Publicado: (2023)

IL-6/IL-12 Cytokine Receptor Shuffling of Extra- and Intracellular Domains Reveals Canonical STAT Activation via Synthetic IL-35 and IL-39 Signaling
por: Floss, D. M., et al.
Publicado: (2017)

Recombinant p35 from Bacteria Can Form Interleukin (IL-)12, but Not IL-35
por: Aparicio-Siegmund, Samadhi, et al.
Publicado: (2014)

Defining the functional binding sites of interleukin 12 receptor β1 and interleukin 23 receptor to Janus kinases
por: Floss, Doreen M., et al.
Publicado: (2016)

The Dichotomous Pattern of IL-12R and IL-23R Expression Elucidates the Role of IL-12 and IL-23 in Inflammation
por: Chognard, Gaëlle, et al.
Publicado: (2014)

Regulation of Antitumor Immune Responses by the IL-12 Family Cytokines, IL-12, IL-23, and IL-27
por: Xu, Mingli, et al.
Publicado: (2010)

Systematic review: IL-12/23 or IL-23 antagonists and RTIs or ILD
Publicado: (2020)

Targeting IL-6 trans-signalling: past, present and future prospects
por: Rose-John, Stefan, et al.
Publicado: (2023)

Synthetic receptor platform to identify loss-of-function single nucleotide variants and designed mutants in the death receptor Fas/CD95
por: Minafra, Anna Rita, et al.
Publicado: (2023)

The role of IL-12, IL-23 and IFN-γ in immunity to viruses
por: Novelli, Francesco, et al.
Publicado: (2004)

Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
por: Mossner, Sofie, et al.
Publicado: (2021)

Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis
por: Rey, Imelda, et al.
Publicado: (2021)

IL-12– and IL-23–modulated T cells induce distinct types of EAE based on histology, CNS chemokine profile, and response to cytokine inhibition
por: Kroenke, Mark A., et al.
Publicado: (2008)

Immunology of IL-12: An update on functional activities and implications for disease
por: Ullrich, Karen A.-M., et al.
Publicado: (2020)

Clinical, Serological and Immunological Characteristics in Greek Patients with Psoriatic Arthritis: The Role of IL-17, IL-23, and Sclerostin
por: Venetsanopoulou, Aliki I., et al.
Publicado: (2020)

Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae
por: Happel, Kyle I., et al.
Publicado: (2005)

Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation
por: Murphy, Craig A., et al.
Publicado: (2003)

Investigation of association of the IL12B and IL23R genes with psoriatic arthritis
por: Filer, Charlotte, et al.
Publicado: (2008)

Interleukin (IL)-12 and IL-18 Synergize to Promote MAIT Cell IL-17A and IL-17F Production Independently of IL-23 Signaling
por: Cole, Suzanne, et al.
Publicado: (2020)

IL-6, IL-12, and IL-23 STAT-Pathway Genetic Risk and Responsiveness of Lymphocytes in Patients with Multiple Sclerosis
por: von Essen, Marina R., et al.
Publicado: (2019)

Control and consequences of IL-6 receptor ectodomain shedding
por: Scheller, Jürgen
Publicado: (2014)

Cratylia mollis 1, 4 Lectin: A New Biotechnological Tool in IL-6, IL-17A, IL-22, and IL-23 Induction and Generation of Immunological Memory
por: de Oliveira, Priscilla Stela Santana, et al.
Publicado: (2013)

Apilimod Inhibits the Production of IL-12 and IL-23 and Reduces Dendritic Cell Infiltration in Psoriasis
por: Wada, Yumiko, et al.
Publicado: (2012)

Epigenetic regulation of Il12 and Il23 gene expression and autoimmune inflammation by the deubiquitinase Trabid
por: Jin, Jin, et al.
Publicado: (2016)

IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders
por: Xu, Jiajia, et al.
Publicado: (2020)

Comment on: Drug Survival of IL‑12/23, IL‑17 and IL‑23 Inhibitors for Psoriasis Treatment: A Retrospective Multi‑Country, Multicentric Cohort Study
por: Borg, Emma, et al.
Publicado: (2021)

The influence of JNK and P38 MAPK inhibition on IL-12P40 and IL-23 production depending on IL12B promoter polymorphism
por: Dobreva, Zlatka Georgieva, et al.
Publicado: (2009)

The role of IL‐23 and the use of IL‐23 inhibitors in psoriatic arthritis
por: Fragoulis, George E., et al.
Publicado: (2022)

Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways
por: Dennehy, Kevin M, et al.
Publicado: (2009)

IL-12– and IL-23–induced T helper cell subsets: birds of the same feather flock together
por: Bettelli, Estelle, et al.
Publicado: (2005)

Therapeutic effect of the potent IL-12/IL-23 inhibitor STA-5326 on experimental autoimmune uveoretinitis
por: Keino, Hiroshi, et al.
Publicado: (2008)

Targeting the IL-12/IL-23 axis: An alternative approach to removing tumor induced immune suppression
por: Smyth, Mark J, et al.
Publicado: (2014)

Successful treatment with the IL12/IL23 antagonist ustekinumab in a patient with refractory Takayasu arteritis
por: Saur, Sebastian-Jonas, et al.
Publicado: (2021)

IL12/23 Blockade with Ustekinumab as a Treatment for Immune-Related Cutaneous Adverse Events
por: Gu, Stephanie L., et al.
Publicado: (2023)

The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection
por: Heimesaat, Markus M., et al.
Publicado: (2016)

Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases
por: Qu, Ning, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_5bqtm2tcovbhkh4u4trntbl1oc