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Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort

Higher serum magnesium is associated with lower risk of multiple morbidities, including diabetes, stroke, and atrial fibrillation, but its potential neuroprotective properties have also been gaining traction in cognitive function and decline research. We studied 12,040 participants presumed free of...

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Autores principales: Alam, Aniqa B., Lutsey, Pamela L., Gottesman, Rebecca F., Tin, Adrienne, Alonso, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600951/
https://www.ncbi.nlm.nih.gov/pubmed/33050118
http://dx.doi.org/10.3390/nu12103074
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author Alam, Aniqa B.
Lutsey, Pamela L.
Gottesman, Rebecca F.
Tin, Adrienne
Alonso, Alvaro
author_facet Alam, Aniqa B.
Lutsey, Pamela L.
Gottesman, Rebecca F.
Tin, Adrienne
Alonso, Alvaro
author_sort Alam, Aniqa B.
collection PubMed
description Higher serum magnesium is associated with lower risk of multiple morbidities, including diabetes, stroke, and atrial fibrillation, but its potential neuroprotective properties have also been gaining traction in cognitive function and decline research. We studied 12,040 participants presumed free of dementia in the Atherosclerosis Risk in Communities (ARIC) study. Serum magnesium was measured in fasting blood samples collected in 1990–1992. Dementia status was ascertained through cognitive examinations in 2011–2013, 2016–2017, and 2018–2019, along with informant interviews and indicators of dementia-related hospitalization events and death. Participants’ cognitive functioning capabilities were assessed up to five times between 1990–1992 and 2018–2019. The cognitive function of participants who did not attend follow-up study visits was imputed to account for attrition. We identified 2519 cases of dementia over a median follow-up period of 24.2 years. The lowest quintile of serum magnesium was associated with a 24% higher rate of incident dementia compared to those in the highest quintile of magnesium (HR, 1.24; 95% CI, 1.07, 1.44). No relationship was found between serum magnesium and cognitive decline in any cognitive domain. Low midlife serum magnesium is associated with increased risk of incident dementia, but does not appear to impact rates of cognitive decline.
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spelling pubmed-76009512020-11-01 Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort Alam, Aniqa B. Lutsey, Pamela L. Gottesman, Rebecca F. Tin, Adrienne Alonso, Alvaro Nutrients Article Higher serum magnesium is associated with lower risk of multiple morbidities, including diabetes, stroke, and atrial fibrillation, but its potential neuroprotective properties have also been gaining traction in cognitive function and decline research. We studied 12,040 participants presumed free of dementia in the Atherosclerosis Risk in Communities (ARIC) study. Serum magnesium was measured in fasting blood samples collected in 1990–1992. Dementia status was ascertained through cognitive examinations in 2011–2013, 2016–2017, and 2018–2019, along with informant interviews and indicators of dementia-related hospitalization events and death. Participants’ cognitive functioning capabilities were assessed up to five times between 1990–1992 and 2018–2019. The cognitive function of participants who did not attend follow-up study visits was imputed to account for attrition. We identified 2519 cases of dementia over a median follow-up period of 24.2 years. The lowest quintile of serum magnesium was associated with a 24% higher rate of incident dementia compared to those in the highest quintile of magnesium (HR, 1.24; 95% CI, 1.07, 1.44). No relationship was found between serum magnesium and cognitive decline in any cognitive domain. Low midlife serum magnesium is associated with increased risk of incident dementia, but does not appear to impact rates of cognitive decline. MDPI 2020-10-09 /pmc/articles/PMC7600951/ /pubmed/33050118 http://dx.doi.org/10.3390/nu12103074 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alam, Aniqa B.
Lutsey, Pamela L.
Gottesman, Rebecca F.
Tin, Adrienne
Alonso, Alvaro
Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort
title Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort
title_full Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort
title_fullStr Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort
title_full_unstemmed Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort
title_short Low Serum Magnesium is Associated with Incident Dementia in the ARIC-NCS Cohort
title_sort low serum magnesium is associated with incident dementia in the aric-ncs cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600951/
https://www.ncbi.nlm.nih.gov/pubmed/33050118
http://dx.doi.org/10.3390/nu12103074
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