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Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?

Brain ischemia after central nervous system (CNS) bleeding significantly influences the final outcome of patients. Catalytic activities of aspartate aminotransferase (AST) in the cerebrospinal fluid (CSF) to detect brain ischemia were determined in this study. The principal aim of our study was to c...

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Autores principales: Kelbich, Petr, Radovnický, Tomáš, Selke-Krulichová, Iva, Lodin, Jan, Matuchová, Inka, Sameš, Martin, Procházka, Jan, Krejsek, Jan, Hanuljaková, Eva, Hejčl, Aleš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600957/
https://www.ncbi.nlm.nih.gov/pubmed/33019758
http://dx.doi.org/10.3390/brainsci10100698
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author Kelbich, Petr
Radovnický, Tomáš
Selke-Krulichová, Iva
Lodin, Jan
Matuchová, Inka
Sameš, Martin
Procházka, Jan
Krejsek, Jan
Hanuljaková, Eva
Hejčl, Aleš
author_facet Kelbich, Petr
Radovnický, Tomáš
Selke-Krulichová, Iva
Lodin, Jan
Matuchová, Inka
Sameš, Martin
Procházka, Jan
Krejsek, Jan
Hanuljaková, Eva
Hejčl, Aleš
author_sort Kelbich, Petr
collection PubMed
description Brain ischemia after central nervous system (CNS) bleeding significantly influences the final outcome of patients. Catalytic activities of aspartate aminotransferase (AST) in the cerebrospinal fluid (CSF) to detect brain ischemia were determined in this study. The principal aim of our study was to compare the dynamics of AST in 1956 CSF samples collected from 215 patients within a 3-week period after CNS hemorrhage. We compared concentrations of the AST catalytic activities in the CSF of two patient groups: survivors (Glasgow Outcome Score (GOS) 5–3) and patients in a vegetative state or dead (GOS 2–1). All statistical evaluations were performed using mixed models and the F-test adjusted by Kenward and Roger and the Bonferroni adjustment for multiple tests. The significantly higher catalytic activities of AST in the CSF from patients with the GOS of 2–1 when compared to those who survived (GOS 5–3, p = 0.001) were found immediately after CNS haemorrhage. In the further course of time, the difference even increased (p < 0.001). This study confirmed the key association between early signs of brain damage evidenced as an elevated AST activity and the prediction of the final patient’s clinical outcome. The study showed that the level of AST in the CSF could be the relevant diagnostic biomarker of the presence and intensity of brain tissue damage.
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spelling pubmed-76009572020-11-01 Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter? Kelbich, Petr Radovnický, Tomáš Selke-Krulichová, Iva Lodin, Jan Matuchová, Inka Sameš, Martin Procházka, Jan Krejsek, Jan Hanuljaková, Eva Hejčl, Aleš Brain Sci Article Brain ischemia after central nervous system (CNS) bleeding significantly influences the final outcome of patients. Catalytic activities of aspartate aminotransferase (AST) in the cerebrospinal fluid (CSF) to detect brain ischemia were determined in this study. The principal aim of our study was to compare the dynamics of AST in 1956 CSF samples collected from 215 patients within a 3-week period after CNS hemorrhage. We compared concentrations of the AST catalytic activities in the CSF of two patient groups: survivors (Glasgow Outcome Score (GOS) 5–3) and patients in a vegetative state or dead (GOS 2–1). All statistical evaluations were performed using mixed models and the F-test adjusted by Kenward and Roger and the Bonferroni adjustment for multiple tests. The significantly higher catalytic activities of AST in the CSF from patients with the GOS of 2–1 when compared to those who survived (GOS 5–3, p = 0.001) were found immediately after CNS haemorrhage. In the further course of time, the difference even increased (p < 0.001). This study confirmed the key association between early signs of brain damage evidenced as an elevated AST activity and the prediction of the final patient’s clinical outcome. The study showed that the level of AST in the CSF could be the relevant diagnostic biomarker of the presence and intensity of brain tissue damage. MDPI 2020-10-01 /pmc/articles/PMC7600957/ /pubmed/33019758 http://dx.doi.org/10.3390/brainsci10100698 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kelbich, Petr
Radovnický, Tomáš
Selke-Krulichová, Iva
Lodin, Jan
Matuchová, Inka
Sameš, Martin
Procházka, Jan
Krejsek, Jan
Hanuljaková, Eva
Hejčl, Aleš
Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?
title Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?
title_full Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?
title_fullStr Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?
title_full_unstemmed Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?
title_short Can Aspartate Aminotransferase in the Cerebrospinal Fluid Be a Reliable Predictive Parameter?
title_sort can aspartate aminotransferase in the cerebrospinal fluid be a reliable predictive parameter?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7600957/
https://www.ncbi.nlm.nih.gov/pubmed/33019758
http://dx.doi.org/10.3390/brainsci10100698
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