Cargando…

BALSAM—An Interactive Online Platform for Breath Analysis, Visualization and Classification

The field of breath analysis lacks a fully automated analysis platform that enforces machine learning good practice and enables clinicians and clinical researchers to rapidly and reproducibly discover metabolite patterns in diseases. We present BALSAM—a comprehensive web-platform to simplify and aut...

Descripción completa

Detalles Bibliográficos
Autores principales: Weber, Philipp, Pauling, Josch Konstantin, List, Markus, Baumbach, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601018/
https://www.ncbi.nlm.nih.gov/pubmed/33023186
http://dx.doi.org/10.3390/metabo10100393
_version_ 1783603298043953152
author Weber, Philipp
Pauling, Josch Konstantin
List, Markus
Baumbach, Jan
author_facet Weber, Philipp
Pauling, Josch Konstantin
List, Markus
Baumbach, Jan
author_sort Weber, Philipp
collection PubMed
description The field of breath analysis lacks a fully automated analysis platform that enforces machine learning good practice and enables clinicians and clinical researchers to rapidly and reproducibly discover metabolite patterns in diseases. We present BALSAM—a comprehensive web-platform to simplify and automate this process, offering features for preprocessing, peak detection, feature extraction, visualization and pattern discovery. Our main focus is on data from multi-capillary-column ion-mobility-spectrometry. While not limited to breath data, BALSAM was developed to increase consistency and robustness in the data analysis process of breath samples, aiming to expand the array of low cost molecular diagnostics in clinics. Our platform is freely available as a web-service and in form of a publicly available docker container.
format Online
Article
Text
id pubmed-7601018
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76010182020-11-01 BALSAM—An Interactive Online Platform for Breath Analysis, Visualization and Classification Weber, Philipp Pauling, Josch Konstantin List, Markus Baumbach, Jan Metabolites Article The field of breath analysis lacks a fully automated analysis platform that enforces machine learning good practice and enables clinicians and clinical researchers to rapidly and reproducibly discover metabolite patterns in diseases. We present BALSAM—a comprehensive web-platform to simplify and automate this process, offering features for preprocessing, peak detection, feature extraction, visualization and pattern discovery. Our main focus is on data from multi-capillary-column ion-mobility-spectrometry. While not limited to breath data, BALSAM was developed to increase consistency and robustness in the data analysis process of breath samples, aiming to expand the array of low cost molecular diagnostics in clinics. Our platform is freely available as a web-service and in form of a publicly available docker container. MDPI 2020-10-02 /pmc/articles/PMC7601018/ /pubmed/33023186 http://dx.doi.org/10.3390/metabo10100393 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Weber, Philipp
Pauling, Josch Konstantin
List, Markus
Baumbach, Jan
BALSAM—An Interactive Online Platform for Breath Analysis, Visualization and Classification
title BALSAM—An Interactive Online Platform for Breath Analysis, Visualization and Classification
title_full BALSAM—An Interactive Online Platform for Breath Analysis, Visualization and Classification
title_fullStr BALSAM—An Interactive Online Platform for Breath Analysis, Visualization and Classification
title_full_unstemmed BALSAM—An Interactive Online Platform for Breath Analysis, Visualization and Classification
title_short BALSAM—An Interactive Online Platform for Breath Analysis, Visualization and Classification
title_sort balsam—an interactive online platform for breath analysis, visualization and classification
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601018/
https://www.ncbi.nlm.nih.gov/pubmed/33023186
http://dx.doi.org/10.3390/metabo10100393
work_keys_str_mv AT weberphilipp balsamaninteractiveonlineplatformforbreathanalysisvisualizationandclassification
AT paulingjoschkonstantin balsamaninteractiveonlineplatformforbreathanalysisvisualizationandclassification
AT listmarkus balsamaninteractiveonlineplatformforbreathanalysisvisualizationandclassification
AT baumbachjan balsamaninteractiveonlineplatformforbreathanalysisvisualizationandclassification