A Single Nucleotide ADA Genetic Variant Is Associated to Central Inflammation and Clinical Presentation in MS: Implications for Cladribine Treatment

In multiple sclerosis (MS), activated T and B lymphocytes and microglial cells release various proinflammatory cytokines, promoting neuroinflammation and negatively affecting the course of the disease. The immune response homeostasis is crucially regulated by the activity of the enzyme adenosine dea...

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Detalles Bibliográficos
Autores principales: Stampanoni Bassi, Mario, Buttari, Fabio, Simonelli, Ilaria, Gilio, Luana, Furlan, Roberto, Finardi, Annamaria, Marfia, Girolama Alessandra, Visconti, Andrea, Paolillo, Andrea, Storto, Marianna, Gambardella, Stefano, Ferese, Rosangela, Salvetti, Marco, Uccelli, Antonio, Matarese, Giuseppe, Centonze, Diego, De Vito, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601054/
https://www.ncbi.nlm.nih.gov/pubmed/33007809
http://dx.doi.org/10.3390/genes11101152

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