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Mechanistic Actions of microRNAs in Diabetic Wound Healing

Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nuc...

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Autores principales: Petkovic, Marija, Sørensen, Anja Elaine, Leal, Ermelindo Carreira, Carvalho, Eugenia, Dalgaard, Louise Torp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601058/
https://www.ncbi.nlm.nih.gov/pubmed/33023156
http://dx.doi.org/10.3390/cells9102228
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author Petkovic, Marija
Sørensen, Anja Elaine
Leal, Ermelindo Carreira
Carvalho, Eugenia
Dalgaard, Louise Torp
author_facet Petkovic, Marija
Sørensen, Anja Elaine
Leal, Ermelindo Carreira
Carvalho, Eugenia
Dalgaard, Louise Torp
author_sort Petkovic, Marija
collection PubMed
description Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers.
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spelling pubmed-76010582020-11-01 Mechanistic Actions of microRNAs in Diabetic Wound Healing Petkovic, Marija Sørensen, Anja Elaine Leal, Ermelindo Carreira Carvalho, Eugenia Dalgaard, Louise Torp Cells Review Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers. MDPI 2020-10-02 /pmc/articles/PMC7601058/ /pubmed/33023156 http://dx.doi.org/10.3390/cells9102228 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Petkovic, Marija
Sørensen, Anja Elaine
Leal, Ermelindo Carreira
Carvalho, Eugenia
Dalgaard, Louise Torp
Mechanistic Actions of microRNAs in Diabetic Wound Healing
title Mechanistic Actions of microRNAs in Diabetic Wound Healing
title_full Mechanistic Actions of microRNAs in Diabetic Wound Healing
title_fullStr Mechanistic Actions of microRNAs in Diabetic Wound Healing
title_full_unstemmed Mechanistic Actions of microRNAs in Diabetic Wound Healing
title_short Mechanistic Actions of microRNAs in Diabetic Wound Healing
title_sort mechanistic actions of micrornas in diabetic wound healing
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601058/
https://www.ncbi.nlm.nih.gov/pubmed/33023156
http://dx.doi.org/10.3390/cells9102228
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