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Mechanistic Actions of microRNAs in Diabetic Wound Healing
Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nuc...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601058/ https://www.ncbi.nlm.nih.gov/pubmed/33023156 http://dx.doi.org/10.3390/cells9102228 |
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author | Petkovic, Marija Sørensen, Anja Elaine Leal, Ermelindo Carreira Carvalho, Eugenia Dalgaard, Louise Torp |
author_facet | Petkovic, Marija Sørensen, Anja Elaine Leal, Ermelindo Carreira Carvalho, Eugenia Dalgaard, Louise Torp |
author_sort | Petkovic, Marija |
collection | PubMed |
description | Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers. |
format | Online Article Text |
id | pubmed-7601058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76010582020-11-01 Mechanistic Actions of microRNAs in Diabetic Wound Healing Petkovic, Marija Sørensen, Anja Elaine Leal, Ermelindo Carreira Carvalho, Eugenia Dalgaard, Louise Torp Cells Review Wound healing is a complex biological process that is impaired under diabetes conditions. Chronic non-healing wounds in diabetes are some of the most expensive healthcare expenditures worldwide. Early diagnosis and efficacious treatment strategies are needed. microRNAs (miRNAs), a class of 18–25 nucleotide long RNAs, are important regulatory molecules involved in gene expression regulation and in the repression of translation, controlling protein expression in health and disease. Recently, miRNAs have emerged as critical players in impaired wound healing and could be targets for potential therapies for non-healing wounds. Here, we review and discuss the mechanistic background of miRNA actions in chronic wounds that can shed the light on their utilization as specific wound healing biomarkers. MDPI 2020-10-02 /pmc/articles/PMC7601058/ /pubmed/33023156 http://dx.doi.org/10.3390/cells9102228 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Petkovic, Marija Sørensen, Anja Elaine Leal, Ermelindo Carreira Carvalho, Eugenia Dalgaard, Louise Torp Mechanistic Actions of microRNAs in Diabetic Wound Healing |
title | Mechanistic Actions of microRNAs in Diabetic Wound Healing |
title_full | Mechanistic Actions of microRNAs in Diabetic Wound Healing |
title_fullStr | Mechanistic Actions of microRNAs in Diabetic Wound Healing |
title_full_unstemmed | Mechanistic Actions of microRNAs in Diabetic Wound Healing |
title_short | Mechanistic Actions of microRNAs in Diabetic Wound Healing |
title_sort | mechanistic actions of micrornas in diabetic wound healing |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601058/ https://www.ncbi.nlm.nih.gov/pubmed/33023156 http://dx.doi.org/10.3390/cells9102228 |
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