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Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization Against PARP1 Inhibition in a Replication-Dependent Manner

SIMPLE SUMMARY: The poor prognosis of patients with TNBC have fostered a major effort to identify more patients who would benefit from targeted therapies. Here we recognize PTEN as a potential CIN-causing gene in TNBC and consider PTEN-deficient TNBC for the treatment with PARP1 inhibitors due to th...

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Detalles Bibliográficos
Autores principales:	Rieckhoff, Johanna, Meyer, Felix, Classen, Sandra, Zielinski, Alexandra, Riepen, Britta, Wikman, Harriet, Petersen, Cordula, Rothkamm, Kai, Borgmann, Kerstin, Parplys, Ann Christin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601067/ https://www.ncbi.nlm.nih.gov/pubmed/33003585 http://dx.doi.org/10.3390/cancers12102809

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