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Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review

The accumulation of blood proteins and cells on extracorporeal membrane oxygenation (ECMO) circuits has been proposed as a contributing factor to the coagulopathic state of many patients. This systematic review aims to summarize and discuss the existing knowledge of blood components binding to the E...

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Autores principales: Callaghan, Sam, Cai, Tengyi, McCafferty, Conor, Van Den Helm, Suelyn, Horton, Steve, MacLaren, Graeme, Monagle, Paul, Ignjatovic, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601136/
https://www.ncbi.nlm.nih.gov/pubmed/33053879
http://dx.doi.org/10.3390/jcm9103272
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author Callaghan, Sam
Cai, Tengyi
McCafferty, Conor
Van Den Helm, Suelyn
Horton, Steve
MacLaren, Graeme
Monagle, Paul
Ignjatovic, Vera
author_facet Callaghan, Sam
Cai, Tengyi
McCafferty, Conor
Van Den Helm, Suelyn
Horton, Steve
MacLaren, Graeme
Monagle, Paul
Ignjatovic, Vera
author_sort Callaghan, Sam
collection PubMed
description The accumulation of blood proteins and cells on extracorporeal membrane oxygenation (ECMO) circuits has been proposed as a contributing factor to the coagulopathic state of many patients. This systematic review aims to summarize and discuss the existing knowledge of blood components binding to the ECMO circuits in human patients. A systematic review was conducted using the Medline, PubMed and Embase databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Seven studies were included in this review. Three studies identified a leukocyte adhesion, three studies observed von Willebrand factor accumulation and four studies identified bound platelets on the surface of the circuits. Other identified components included fibrin, albumin, hemoglobin, erythrocytes, progenitor cells, fibronectin and IgG. This systematic review demonstrates the limited state of knowledge when it comes to adsorption to the ECMO circuits in humans. Most of the studies lacked insight or detail into the mechanisms of binding and the interactions between different components bound to the ECMO circuits. Further research is required to comprehensively characterize surface adsorption to ECMO circuits in humans and to define the specific mechanisms of binding, enabling improvements that increase biocompatibility between the blood-circuit interface in this important clinical setting.
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spelling pubmed-76011362020-11-01 Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review Callaghan, Sam Cai, Tengyi McCafferty, Conor Van Den Helm, Suelyn Horton, Steve MacLaren, Graeme Monagle, Paul Ignjatovic, Vera J Clin Med Review The accumulation of blood proteins and cells on extracorporeal membrane oxygenation (ECMO) circuits has been proposed as a contributing factor to the coagulopathic state of many patients. This systematic review aims to summarize and discuss the existing knowledge of blood components binding to the ECMO circuits in human patients. A systematic review was conducted using the Medline, PubMed and Embase databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Seven studies were included in this review. Three studies identified a leukocyte adhesion, three studies observed von Willebrand factor accumulation and four studies identified bound platelets on the surface of the circuits. Other identified components included fibrin, albumin, hemoglobin, erythrocytes, progenitor cells, fibronectin and IgG. This systematic review demonstrates the limited state of knowledge when it comes to adsorption to the ECMO circuits in humans. Most of the studies lacked insight or detail into the mechanisms of binding and the interactions between different components bound to the ECMO circuits. Further research is required to comprehensively characterize surface adsorption to ECMO circuits in humans and to define the specific mechanisms of binding, enabling improvements that increase biocompatibility between the blood-circuit interface in this important clinical setting. MDPI 2020-10-12 /pmc/articles/PMC7601136/ /pubmed/33053879 http://dx.doi.org/10.3390/jcm9103272 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Callaghan, Sam
Cai, Tengyi
McCafferty, Conor
Van Den Helm, Suelyn
Horton, Steve
MacLaren, Graeme
Monagle, Paul
Ignjatovic, Vera
Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review
title Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review
title_full Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review
title_fullStr Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review
title_full_unstemmed Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review
title_short Adsorption of Blood Components to Extracorporeal Membrane Oxygenation (ECMO) Surfaces in Humans: A Systematic Review
title_sort adsorption of blood components to extracorporeal membrane oxygenation (ecmo) surfaces in humans: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601136/
https://www.ncbi.nlm.nih.gov/pubmed/33053879
http://dx.doi.org/10.3390/jcm9103272
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