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Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials

Pancreatic adenocarcinoma (PDAC) originates in the glandular compartment of the exocrine pancreas. Histologically, PDAC tumors are characterized by a parenchyma that is embedded in a particularly prominent stromal component or desmoplastic stroma. The unique characteristics of the desmoplastic strom...

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Autores principales: Mejia, Isabel, Bodapati, Sandhya, Chen, Kathryn T., Díaz, Begoña
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601142/
https://www.ncbi.nlm.nih.gov/pubmed/33050151
http://dx.doi.org/10.3390/biomedicines8100401
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author Mejia, Isabel
Bodapati, Sandhya
Chen, Kathryn T.
Díaz, Begoña
author_facet Mejia, Isabel
Bodapati, Sandhya
Chen, Kathryn T.
Díaz, Begoña
author_sort Mejia, Isabel
collection PubMed
description Pancreatic adenocarcinoma (PDAC) originates in the glandular compartment of the exocrine pancreas. Histologically, PDAC tumors are characterized by a parenchyma that is embedded in a particularly prominent stromal component or desmoplastic stroma. The unique characteristics of the desmoplastic stroma shape the microenvironment of PDAC and modulate the reciprocal interactions between cancer and stromal cells in ways that have profound effects in the pathophysiology and treatment of this disease. Here, we review some of the most recent findings regarding the regulation of PDAC cell invasion by the unique microenvironment of this tumor, and how new knowledge is being translated into novel therapeutic approaches.
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spelling pubmed-76011422020-11-01 Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials Mejia, Isabel Bodapati, Sandhya Chen, Kathryn T. Díaz, Begoña Biomedicines Review Pancreatic adenocarcinoma (PDAC) originates in the glandular compartment of the exocrine pancreas. Histologically, PDAC tumors are characterized by a parenchyma that is embedded in a particularly prominent stromal component or desmoplastic stroma. The unique characteristics of the desmoplastic stroma shape the microenvironment of PDAC and modulate the reciprocal interactions between cancer and stromal cells in ways that have profound effects in the pathophysiology and treatment of this disease. Here, we review some of the most recent findings regarding the regulation of PDAC cell invasion by the unique microenvironment of this tumor, and how new knowledge is being translated into novel therapeutic approaches. MDPI 2020-10-09 /pmc/articles/PMC7601142/ /pubmed/33050151 http://dx.doi.org/10.3390/biomedicines8100401 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mejia, Isabel
Bodapati, Sandhya
Chen, Kathryn T.
Díaz, Begoña
Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
title Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
title_full Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
title_fullStr Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
title_full_unstemmed Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
title_short Pancreatic Adenocarcinoma Invasiveness and the Tumor Microenvironment: From Biology to Clinical Trials
title_sort pancreatic adenocarcinoma invasiveness and the tumor microenvironment: from biology to clinical trials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601142/
https://www.ncbi.nlm.nih.gov/pubmed/33050151
http://dx.doi.org/10.3390/biomedicines8100401
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