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An Analysis and Comparison of Survival and Functional Outcomes in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiation Therapy within City of Hope Cancer Center Sites
Oropharyngeal squamous cell carcinoma (OPSCC) is a subset of head and neck cancers that can arise due to human papillomavirus (HPV) infection. We designed a retrospective analysis to determine differences in outcomes of OPSCC patients treated at City of Hope (COH) Cancer Center’s main campus versus...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601157/ https://www.ncbi.nlm.nih.gov/pubmed/32987866 http://dx.doi.org/10.3390/jcm9103083 |
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author | Pharaon, Rebecca Chung, Samuel Amini, Arya Maghami, Ellie Chowdhury, Arnab Vora, Nayana Chang, Sue Kang, Robert Gernon, Thomas Hansen, Kelly Kelly, Christina Ackerman, Denise Vora, Lalit Sampath, Sagus Massarelli, Erminia |
author_facet | Pharaon, Rebecca Chung, Samuel Amini, Arya Maghami, Ellie Chowdhury, Arnab Vora, Nayana Chang, Sue Kang, Robert Gernon, Thomas Hansen, Kelly Kelly, Christina Ackerman, Denise Vora, Lalit Sampath, Sagus Massarelli, Erminia |
author_sort | Pharaon, Rebecca |
collection | PubMed |
description | Oropharyngeal squamous cell carcinoma (OPSCC) is a subset of head and neck cancers that can arise due to human papillomavirus (HPV) infection. We designed a retrospective analysis to determine differences in outcomes of OPSCC patients treated at City of Hope (COH) Cancer Center’s main campus versus selected satellite sites with COH-associated faculty and facilities. Patients diagnosed with OPSCC and treated with concurrent chemoradiation therapy (n = 94) were identified and included in the study. Patients underwent treatment at the COH main campus site (n = 50) or satellite sites (n = 44). The majority of patients were Caucasian, male, and diagnosed with p16 positive stage IV locally advanced OPSCC by AJCC 7th edition. Most patients completed their prescribed cumulative radiation therapy dose and had a complete response to treatment. No significant difference in overall survival and progression-free survival was observed between the main campus and the satellite sites. Our study demonstrates successful treatment completion rates as well as comparable recurrence rates between the main campus and COH-associated satellite sites. A trend toward significant difference in feeding tube dependency at 6-months was observed. Differences in feeding tube placement and dependency rates could be addressed by the establishment of on-site supportive services in satellite sites. |
format | Online Article Text |
id | pubmed-7601157 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76011572020-11-01 An Analysis and Comparison of Survival and Functional Outcomes in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiation Therapy within City of Hope Cancer Center Sites Pharaon, Rebecca Chung, Samuel Amini, Arya Maghami, Ellie Chowdhury, Arnab Vora, Nayana Chang, Sue Kang, Robert Gernon, Thomas Hansen, Kelly Kelly, Christina Ackerman, Denise Vora, Lalit Sampath, Sagus Massarelli, Erminia J Clin Med Article Oropharyngeal squamous cell carcinoma (OPSCC) is a subset of head and neck cancers that can arise due to human papillomavirus (HPV) infection. We designed a retrospective analysis to determine differences in outcomes of OPSCC patients treated at City of Hope (COH) Cancer Center’s main campus versus selected satellite sites with COH-associated faculty and facilities. Patients diagnosed with OPSCC and treated with concurrent chemoradiation therapy (n = 94) were identified and included in the study. Patients underwent treatment at the COH main campus site (n = 50) or satellite sites (n = 44). The majority of patients were Caucasian, male, and diagnosed with p16 positive stage IV locally advanced OPSCC by AJCC 7th edition. Most patients completed their prescribed cumulative radiation therapy dose and had a complete response to treatment. No significant difference in overall survival and progression-free survival was observed between the main campus and the satellite sites. Our study demonstrates successful treatment completion rates as well as comparable recurrence rates between the main campus and COH-associated satellite sites. A trend toward significant difference in feeding tube dependency at 6-months was observed. Differences in feeding tube placement and dependency rates could be addressed by the establishment of on-site supportive services in satellite sites. MDPI 2020-09-24 /pmc/articles/PMC7601157/ /pubmed/32987866 http://dx.doi.org/10.3390/jcm9103083 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pharaon, Rebecca Chung, Samuel Amini, Arya Maghami, Ellie Chowdhury, Arnab Vora, Nayana Chang, Sue Kang, Robert Gernon, Thomas Hansen, Kelly Kelly, Christina Ackerman, Denise Vora, Lalit Sampath, Sagus Massarelli, Erminia An Analysis and Comparison of Survival and Functional Outcomes in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiation Therapy within City of Hope Cancer Center Sites |
title | An Analysis and Comparison of Survival and Functional Outcomes in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiation Therapy within City of Hope Cancer Center Sites |
title_full | An Analysis and Comparison of Survival and Functional Outcomes in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiation Therapy within City of Hope Cancer Center Sites |
title_fullStr | An Analysis and Comparison of Survival and Functional Outcomes in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiation Therapy within City of Hope Cancer Center Sites |
title_full_unstemmed | An Analysis and Comparison of Survival and Functional Outcomes in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiation Therapy within City of Hope Cancer Center Sites |
title_short | An Analysis and Comparison of Survival and Functional Outcomes in Oropharyngeal Squamous Cell Carcinoma Patients Treated with Concurrent Chemoradiation Therapy within City of Hope Cancer Center Sites |
title_sort | analysis and comparison of survival and functional outcomes in oropharyngeal squamous cell carcinoma patients treated with concurrent chemoradiation therapy within city of hope cancer center sites |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601157/ https://www.ncbi.nlm.nih.gov/pubmed/32987866 http://dx.doi.org/10.3390/jcm9103083 |
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