CDK 4/6 Inhibition Overcomes Acquired and Inherent Resistance to PI3Kα Inhibition in Pre-Clinical Models of Head and Neck Squamous Cell Carcinoma

Activating alterations in PIK3CA, the gene coding for the catalytic subunit of phosphoinositide-3-kinase (PI3K), are prevalent in head and neck squamous cell carcinoma (HNSCC) and thought to be one of the main drivers of these tumors. However, early clinical trials on PI3K inhibitors (PI3Ki) have be...

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Detalles Bibliográficos
Autores principales: Remer, Eric, Badarni, Mai, Hikri, Elad, Dayan, Avraham, Levi, Lirit, Popovtzer, Aron, Iraqi, Muhammed, Porgador, Angel, Joshua, Ben-Zion, Bachar, Gideon, Elkabets, Moshe, Scaltriti, Maurizio, Mizrachi, Aviram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601167/
https://www.ncbi.nlm.nih.gov/pubmed/33036331
http://dx.doi.org/10.3390/jcm9103214

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