Cargando…

Metformin Enhances Excitatory Synaptic Transmission onto Hippocampal CA1 Pyramidal Neurons

Metformin (Met) is a first-line drug for type 2 diabetes mellitus (T2DM). Numerous studies have shown that Met exerts beneficial effects on a variety of neurological disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD). However, it is still largely un...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Wen-Bing, Chen, Jiang, Liu, Zi-Yang, Luo, Bin, Zhou, Tian, Fei, Er-Kang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601223/ https://www.ncbi.nlm.nih.gov/pubmed/33020379 http://dx.doi.org/10.3390/brainsci10100706

Ejemplares similares

Cannabinoids attenuate hippocampal gamma oscillations by suppressing excitatory synaptic input onto CA3 pyramidal neurons and fast spiking basket cells
por: Holderith, Noémi, et al.
Publicado: (2011)

Acetylcholine Release Inhibits Distinct Excitatory Inputs Onto Hippocampal CA1 Pyramidal Neurons via Different Cellular and Network Mechanisms
por: Goswamee, Priyodarshan, et al.
Publicado: (2019)

STK24 modulates excitatory synaptic transmission in epileptic hippocampal neurons
por: Yang, Juan, et al.
Publicado: (2020)

Location-Dependent Excitatory Synaptic Interactions in Pyramidal Neuron Dendrites
por: Behabadi, Bardia F., et al.
Publicado: (2012)

Endocannabinoids Differentially Modulate Synaptic Plasticity in Rat Hippocampal CA1 Pyramidal Neurons
por: Xu, Jian-Yi, et al.
Publicado: (2010)

Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and parvalbumin-positive interneurons
por: Melander, Joshua B., et al.
Publicado: (2021)

Coexistence of Multiple Types of Synaptic Plasticity in Individual Hippocampal CA1 Pyramidal Neurons
por: Edelmann, Elke, et al.
Publicado: (2017)

Age-dependent regulation of excitatory synaptic transmission at hippocampal temporoammonic-CA1 synapses by leptin
por: McGregor, Gemma, et al.
Publicado: (2018)

Single Prolonged Stress Reduces Intrinsic Excitability and Excitatory Synaptic Drive Onto Pyramidal Neurons in the Infralimbic Prefrontal Cortex of Adult Male Rats
por: Nawreen, Nawshaba, et al.
Publicado: (2021)

Effects of Low Frequency Stimulation on Spontaneous Inhibitory and Excitatory Post-Synaptic Currents in Hippocampal CA1 Pyramidal Cells of Kindled Rats
por: Ghafouri, Samireh, et al.
Publicado: (2017)

Heterogeneous CaMKII-Dependent Synaptic Compensations in CA1 Pyramidal Neurons From Acute Hippocampal Slices
por: Vergara, Pablo, et al.
Publicado: (2022)

A critical role for CaMKII in behavioral timescale synaptic plasticity in hippocampal CA1 pyramidal neurons
por: Xiao, Kuo, et al.
Publicado: (2023)

Autism spectrum disorder-like behavior caused by reduced excitatory synaptic transmission in pyramidal neurons of mouse prefrontal cortex
por: Sacai, Hiroaki, et al.
Publicado: (2020)

Intravenous lipid emulsion modifies synaptic transmission in hippocampal CA1 pyramidal neurons after bupivacaine‐induced central nervous system toxicity
por: Nie, Hao, et al.
Publicado: (2020)

Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons
por: Cabrera, Omar Hoseá, et al.
Publicado: (2022)

Effect of insulin on excitatory synaptic transmission onto dopamine neurons of the ventral tegmental area in a mouse model of hyperinsulinemia
por: Liu, S, et al.
Publicado: (2013)

Interneuron-specific plasticity at parvalbumin and somatostatin inhibitory synapses onto CA1 pyramidal neurons shapes hippocampal output
por: Udakis, Matt, et al.
Publicado: (2020)

Spatiotemporal functional organization of excitatory synaptic inputs onto macaque V1 neurons
por: Ju, Niansheng, et al.
Publicado: (2020)

In Vivo Monosynaptic Excitatory Transmission between Layer 2 Cortical Pyramidal Neurons
por: Jouhanneau, Jean-Sébastien, et al.
Publicado: (2015)

Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch
por: Kanehisa, Kensho, et al.
Publicado: (2022)

Adult-born neurons modify excitatory synaptic transmission to existing neurons
por: Adlaf, Elena W, et al.
Publicado: (2017)

Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function
por: Wu, Min-Yi, et al.
Publicado: (2022)

Variable Dendritic Integration in Hippocampal CA3 Pyramidal Neurons
por: Makara, Judit K., et al.
Publicado: (2013)

Neonatal Propofol and Etomidate Exposure Enhance Inhibitory Synaptic Transmission in Hippocampal Cornus Ammonis 1 Pyramidal Neurons
por: Zhang, Jia-Qiang, et al.
Publicado: (2016)

Differential nanoscale organization of excitatory synapses onto excitatory vs inhibitory neurons
por: Dharmasri, Poorna A., et al.
Publicado: (2023)

Synaptic Effects of Munc18-1 Alternative Splicing in Excitatory Hippocampal Neurons
por: Meijer, Marieke, et al.
Publicado: (2015)

Correction: Adult-born neurons modify excitatory synaptic transmission to existing neurons
por: Adlaf, Elena W, et al.
Publicado: (2022)

Bidirectional Synaptic Plasticity Is Driven by Sex Neurosteroids Targeting Estrogen and Androgen Receptors in Hippocampal CA1 Pyramidal Neurons
por: Tozzi, Alessandro, et al.
Publicado: (2019)

Neuronal MHC Class I Molecules are Involved in Excitatory Synaptic Transmission at the Hippocampal Mossy Fiber Synapses of Marmoset Monkeys
por: Ribic, Adema, et al.
Publicado: (2010)

Hippocampal neurons in direct contact with astrocytes exposed to amyloid β(25-35) exhibit reduced excitatory synaptic transmission
por: Oyabu, Kohei, et al.
Publicado: (2019)

TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons
por: Kougioumoutzakis, André, et al.
Publicado: (2020)

A computational study of the influence of synaptic cooperativity on synaptic plasticity in a hippocampal CA1 pyramidal cell
por: Graham, Bruce P, et al.
Publicado: (2012)

CUX2 deficiency causes facilitation of excitatory synaptic transmission onto hippocampus and increased seizure susceptibility to kainate
por: Suzuki, Toshimitsu, et al.
Publicado: (2022)

Altered integration of excitatory inputs onto the basal dendrites of layer 5 pyramidal neurons in a mouse model of Fragile X syndrome
por: Mitchell, Diana E., et al.
Publicado: (2023)

Effects of low frequency electric fields on synaptic integration in hippocampal CA1 pyramidal neurons: implications for power line emissions
por: Cavarretta, Francesco, et al.
Publicado: (2014)

Repetitive mild traumatic brain injury induces persistent alterations in spontaneous synaptic activity of hippocampal CA1 pyramidal neurons
por: Langlois, Ludovic D., et al.
Publicado: (2022)

Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons
por: Losonczy, Attila, et al.
Publicado: (2010)

Effects of Metabolic Energy on Synaptic Transmission and Dendritic Integration in Pyramidal Neurons
por: Yuan, Ye, et al.
Publicado: (2018)

Inhibition as a Binary Switch for Excitatory Plasticity in Pyramidal Neurons
por: Wilmes, Katharina A., et al.
Publicado: (2016)

Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures
por: Weston, Matthew C., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_plebngc0fsj48f7a545dqdojsg