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Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies

Preeclampsia is a multi-systemic syndrome that presents in approximately 5% of pregnancies worldwide and is associated with a range of subsequent postpartum and postnatal outcomes, including fetal growth restriction. As the placenta plays a critical role in the development of preeclampsia, surveying...

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Autores principales: Deyssenroth, Maya A., Li, Qian, Escudero, Carlos, Myatt, Leslie, Chen, Jia, Roberts, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601230/
https://www.ncbi.nlm.nih.gov/pubmed/33003346
http://dx.doi.org/10.3390/genes11101146
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author Deyssenroth, Maya A.
Li, Qian
Escudero, Carlos
Myatt, Leslie
Chen, Jia
Roberts, James M.
author_facet Deyssenroth, Maya A.
Li, Qian
Escudero, Carlos
Myatt, Leslie
Chen, Jia
Roberts, James M.
author_sort Deyssenroth, Maya A.
collection PubMed
description Preeclampsia is a multi-systemic syndrome that presents in approximately 5% of pregnancies worldwide and is associated with a range of subsequent postpartum and postnatal outcomes, including fetal growth restriction. As the placenta plays a critical role in the development of preeclampsia, surveying genomic features of the placenta, including expression of imprinted genes, may reveal molecular markers that can further refine subtypes to aid targeted disease management. In this study, we conducted a comprehensive survey of placental imprinted gene expression across early and late onset preeclampsia cases and preterm and term normotensive controls. Placentas were collected at delivery from women recruited at the Magee-Womens Hospital prenatal clinics, and expression levels were profiled across 109 imprinted genes. We observed downregulation of placental Mesoderm-specific transcript (MEST) and Necdin (NDN) gene expression levels (false discovery rate (FDR) < 0.05) among early onset preeclampsia cases compared to preterm controls. No differences in placental imprinted gene expression were observed between late onset preeclampsia cases and term controls. While few studies have linked NDN to pregnancy complications, reductions in MEST expression levels, as observed in our study, are consistently reported in the literature in relation to various pregnancy complications, including fetal growth restriction, suggesting a potential role for placental MEST expression as a biosensor of an adverse in utero environment.
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spelling pubmed-76012302020-11-01 Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies Deyssenroth, Maya A. Li, Qian Escudero, Carlos Myatt, Leslie Chen, Jia Roberts, James M. Genes (Basel) Article Preeclampsia is a multi-systemic syndrome that presents in approximately 5% of pregnancies worldwide and is associated with a range of subsequent postpartum and postnatal outcomes, including fetal growth restriction. As the placenta plays a critical role in the development of preeclampsia, surveying genomic features of the placenta, including expression of imprinted genes, may reveal molecular markers that can further refine subtypes to aid targeted disease management. In this study, we conducted a comprehensive survey of placental imprinted gene expression across early and late onset preeclampsia cases and preterm and term normotensive controls. Placentas were collected at delivery from women recruited at the Magee-Womens Hospital prenatal clinics, and expression levels were profiled across 109 imprinted genes. We observed downregulation of placental Mesoderm-specific transcript (MEST) and Necdin (NDN) gene expression levels (false discovery rate (FDR) < 0.05) among early onset preeclampsia cases compared to preterm controls. No differences in placental imprinted gene expression were observed between late onset preeclampsia cases and term controls. While few studies have linked NDN to pregnancy complications, reductions in MEST expression levels, as observed in our study, are consistently reported in the literature in relation to various pregnancy complications, including fetal growth restriction, suggesting a potential role for placental MEST expression as a biosensor of an adverse in utero environment. MDPI 2020-09-29 /pmc/articles/PMC7601230/ /pubmed/33003346 http://dx.doi.org/10.3390/genes11101146 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Deyssenroth, Maya A.
Li, Qian
Escudero, Carlos
Myatt, Leslie
Chen, Jia
Roberts, James M.
Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies
title Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies
title_full Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies
title_fullStr Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies
title_full_unstemmed Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies
title_short Differences in Placental Imprinted Gene Expression across Preeclamptic and Non-Preeclamptic Pregnancies
title_sort differences in placental imprinted gene expression across preeclamptic and non-preeclamptic pregnancies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601230/
https://www.ncbi.nlm.nih.gov/pubmed/33003346
http://dx.doi.org/10.3390/genes11101146
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