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Application of Bacteriophages in Nanotechnology
Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentati...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601235/ https://www.ncbi.nlm.nih.gov/pubmed/33003494 http://dx.doi.org/10.3390/nano10101944 |
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author | Paczesny, Jan Bielec, Krzysztof |
author_facet | Paczesny, Jan Bielec, Krzysztof |
author_sort | Paczesny, Jan |
collection | PubMed |
description | Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentation in complex fluids), or in the material science (e.g., as scaffolds). Nevertheless, phages also execute the life cycle to multiply and produce progeny virions. Upon completion of the life cycle of phages, the host cells are usually destroyed. Natural abilities to bind to and kill bacteria were a starting point for utilizing phages in phage therapies (i.e., medical treatments that use phages to fight bacterial infections) and for bacteria detection. Numerous applications of phages became possible thanks to phage display—a method connecting the phenotype and genotype, which allows for selecting specific peptides or proteins with affinity to a given target. Here, we review the application of bacteriophages in nanoscience, emphasizing bio-related applications, material science, soft matter research, and physical chemistry. |
format | Online Article Text |
id | pubmed-7601235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76012352020-11-01 Application of Bacteriophages in Nanotechnology Paczesny, Jan Bielec, Krzysztof Nanomaterials (Basel) Review Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentation in complex fluids), or in the material science (e.g., as scaffolds). Nevertheless, phages also execute the life cycle to multiply and produce progeny virions. Upon completion of the life cycle of phages, the host cells are usually destroyed. Natural abilities to bind to and kill bacteria were a starting point for utilizing phages in phage therapies (i.e., medical treatments that use phages to fight bacterial infections) and for bacteria detection. Numerous applications of phages became possible thanks to phage display—a method connecting the phenotype and genotype, which allows for selecting specific peptides or proteins with affinity to a given target. Here, we review the application of bacteriophages in nanoscience, emphasizing bio-related applications, material science, soft matter research, and physical chemistry. MDPI 2020-09-29 /pmc/articles/PMC7601235/ /pubmed/33003494 http://dx.doi.org/10.3390/nano10101944 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Paczesny, Jan Bielec, Krzysztof Application of Bacteriophages in Nanotechnology |
title | Application of Bacteriophages in Nanotechnology |
title_full | Application of Bacteriophages in Nanotechnology |
title_fullStr | Application of Bacteriophages in Nanotechnology |
title_full_unstemmed | Application of Bacteriophages in Nanotechnology |
title_short | Application of Bacteriophages in Nanotechnology |
title_sort | application of bacteriophages in nanotechnology |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601235/ https://www.ncbi.nlm.nih.gov/pubmed/33003494 http://dx.doi.org/10.3390/nano10101944 |
work_keys_str_mv | AT paczesnyjan applicationofbacteriophagesinnanotechnology AT bieleckrzysztof applicationofbacteriophagesinnanotechnology |