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Application of Bacteriophages in Nanotechnology

Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentati...

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Detalles Bibliográficos
Autores principales: Paczesny, Jan, Bielec, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601235/
https://www.ncbi.nlm.nih.gov/pubmed/33003494
http://dx.doi.org/10.3390/nano10101944
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author Paczesny, Jan
Bielec, Krzysztof
author_facet Paczesny, Jan
Bielec, Krzysztof
author_sort Paczesny, Jan
collection PubMed
description Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentation in complex fluids), or in the material science (e.g., as scaffolds). Nevertheless, phages also execute the life cycle to multiply and produce progeny virions. Upon completion of the life cycle of phages, the host cells are usually destroyed. Natural abilities to bind to and kill bacteria were a starting point for utilizing phages in phage therapies (i.e., medical treatments that use phages to fight bacterial infections) and for bacteria detection. Numerous applications of phages became possible thanks to phage display—a method connecting the phenotype and genotype, which allows for selecting specific peptides or proteins with affinity to a given target. Here, we review the application of bacteriophages in nanoscience, emphasizing bio-related applications, material science, soft matter research, and physical chemistry.
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spelling pubmed-76012352020-11-01 Application of Bacteriophages in Nanotechnology Paczesny, Jan Bielec, Krzysztof Nanomaterials (Basel) Review Bacteriophages (phages for short) are viruses, which have bacteria as hosts. The single phage body virion, is a colloidal particle, often possessing a dipole moment. As such, phages were used as perfectly monodisperse systems to study various physicochemical phenomena (e.g., transport or sedimentation in complex fluids), or in the material science (e.g., as scaffolds). Nevertheless, phages also execute the life cycle to multiply and produce progeny virions. Upon completion of the life cycle of phages, the host cells are usually destroyed. Natural abilities to bind to and kill bacteria were a starting point for utilizing phages in phage therapies (i.e., medical treatments that use phages to fight bacterial infections) and for bacteria detection. Numerous applications of phages became possible thanks to phage display—a method connecting the phenotype and genotype, which allows for selecting specific peptides or proteins with affinity to a given target. Here, we review the application of bacteriophages in nanoscience, emphasizing bio-related applications, material science, soft matter research, and physical chemistry. MDPI 2020-09-29 /pmc/articles/PMC7601235/ /pubmed/33003494 http://dx.doi.org/10.3390/nano10101944 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paczesny, Jan
Bielec, Krzysztof
Application of Bacteriophages in Nanotechnology
title Application of Bacteriophages in Nanotechnology
title_full Application of Bacteriophages in Nanotechnology
title_fullStr Application of Bacteriophages in Nanotechnology
title_full_unstemmed Application of Bacteriophages in Nanotechnology
title_short Application of Bacteriophages in Nanotechnology
title_sort application of bacteriophages in nanotechnology
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601235/
https://www.ncbi.nlm.nih.gov/pubmed/33003494
http://dx.doi.org/10.3390/nano10101944
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