A Diamine-PEGylated Oleanolic Acid Derivative Induced Efficient Apoptosis through a Death Receptor and Mitochondrial Apoptotic Pathway in HepG2 Human Hepatoma Cells

Hepatocellular carcinoma (HCC) is the most common type of liver cancer. Our recent studies have shown that the diamine-(PEG)ylated oleanolic acid (OADP) has strong anti-tumor effects in HCCs. In this study, we evaluated the anti-tumor mechanisms of OADP in the HepG2 HCC cell line. The cytotoxicity r...

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Detalles Bibliográficos
Autores principales: Jannus, Fatin, Medina-O’Donnell, Marta, Rivas, Francisco, Díaz-Ruiz, Luis, Rufino-Palomares, Eva E., Lupiáñez, José A., Parra, Andrés, Reyes-Zurita, Fernando J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601263/
https://www.ncbi.nlm.nih.gov/pubmed/32998255
http://dx.doi.org/10.3390/biom10101375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601263/
https://www.ncbi.nlm.nih.gov/pubmed/32998255
http://dx.doi.org/10.3390/biom10101375

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