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The Relevance of Selenium Status in Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural comp...

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Autores principales: Turrubiates-Hernández, Francisco Javier, Márquez-Sandoval, Yolanda Fabiola, González-Estevez, Guillermo, Reyes-Castillo, Zyanya, Muñoz-Valle, José Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601319/
https://www.ncbi.nlm.nih.gov/pubmed/33007934
http://dx.doi.org/10.3390/nu12103007
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author Turrubiates-Hernández, Francisco Javier
Márquez-Sandoval, Yolanda Fabiola
González-Estevez, Guillermo
Reyes-Castillo, Zyanya
Muñoz-Valle, José Francisco
author_facet Turrubiates-Hernández, Francisco Javier
Márquez-Sandoval, Yolanda Fabiola
González-Estevez, Guillermo
Reyes-Castillo, Zyanya
Muñoz-Valle, José Francisco
author_sort Turrubiates-Hernández, Francisco Javier
collection PubMed
description Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural component of antioxidant enzymes; however, its concentration can be affected by diet, drugs and genetic polymorphisms. Studies have reported that RA patients have a deficient diet in some food groups that is associated with parameters of disease activity. Furthermore, it has been shown that there is an alteration in serum Se levels in this population. Although some clinical trials have been conducted in the past to analyze the effect of Se supplementation in RA, no significant results were obtained. Contrastingly, experimental studies that have evaluated the effect of novel Se nanoparticles in RA-induced models have shown promising results on the restoration of antioxidant enzyme levels. In particular, glutathione peroxidase (GPx) is an important selenoprotein that could have a modulating effect on inflammation in RA. Considering that RA patients present an inflammatory and oxidative state, the aim of this review is to give an overview of the current knowledge about the relevance of Se status in RA.
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spelling pubmed-76013192020-11-01 The Relevance of Selenium Status in Rheumatoid Arthritis Turrubiates-Hernández, Francisco Javier Márquez-Sandoval, Yolanda Fabiola González-Estevez, Guillermo Reyes-Castillo, Zyanya Muñoz-Valle, José Francisco Nutrients Review Rheumatoid arthritis (RA) is an autoimmune and inflammatory disease that can cause joint damage. Among the environmental risk factors, diet plays an important role because it can aggravate or attenuate inflammation. Selenium (Se) is considered an essential trace element since it is a structural component of antioxidant enzymes; however, its concentration can be affected by diet, drugs and genetic polymorphisms. Studies have reported that RA patients have a deficient diet in some food groups that is associated with parameters of disease activity. Furthermore, it has been shown that there is an alteration in serum Se levels in this population. Although some clinical trials have been conducted in the past to analyze the effect of Se supplementation in RA, no significant results were obtained. Contrastingly, experimental studies that have evaluated the effect of novel Se nanoparticles in RA-induced models have shown promising results on the restoration of antioxidant enzyme levels. In particular, glutathione peroxidase (GPx) is an important selenoprotein that could have a modulating effect on inflammation in RA. Considering that RA patients present an inflammatory and oxidative state, the aim of this review is to give an overview of the current knowledge about the relevance of Se status in RA. MDPI 2020-09-30 /pmc/articles/PMC7601319/ /pubmed/33007934 http://dx.doi.org/10.3390/nu12103007 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Turrubiates-Hernández, Francisco Javier
Márquez-Sandoval, Yolanda Fabiola
González-Estevez, Guillermo
Reyes-Castillo, Zyanya
Muñoz-Valle, José Francisco
The Relevance of Selenium Status in Rheumatoid Arthritis
title The Relevance of Selenium Status in Rheumatoid Arthritis
title_full The Relevance of Selenium Status in Rheumatoid Arthritis
title_fullStr The Relevance of Selenium Status in Rheumatoid Arthritis
title_full_unstemmed The Relevance of Selenium Status in Rheumatoid Arthritis
title_short The Relevance of Selenium Status in Rheumatoid Arthritis
title_sort relevance of selenium status in rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601319/
https://www.ncbi.nlm.nih.gov/pubmed/33007934
http://dx.doi.org/10.3390/nu12103007
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