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Application of Citicoline in Neurological Disorders: A Systematic Review

Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhan...

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Autores principales: Jasielski, Patryk, Piędel, Faustyna, Piwek, Mikołaj, Rocka, Agata, Petit, Véronique, Rejdak, Konrad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601330/
https://www.ncbi.nlm.nih.gov/pubmed/33053828
http://dx.doi.org/10.3390/nu12103113
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author Jasielski, Patryk
Piędel, Faustyna
Piwek, Mikołaj
Rocka, Agata
Petit, Véronique
Rejdak, Konrad
author_facet Jasielski, Patryk
Piędel, Faustyna
Piwek, Mikołaj
Rocka, Agata
Petit, Véronique
Rejdak, Konrad
author_sort Jasielski, Patryk
collection PubMed
description Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhance cognitive functions. In our article, accessible databases were searched for articles regarding citicoline use in neurological diseases. This article has a systemic review form. After rejecting non-eligible reports, 47 remaining articles were reviewed. The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke. In an animal model of nerve damage and neuropathy, citicoline stimulated regeneration and lessened pain. Among patients who underwent brain trauma, citicoline has an unclear clinical effect. Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases. Its positive impact on learning and cognitive functions among the healthy population is also worth noting.
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spelling pubmed-76013302020-11-01 Application of Citicoline in Neurological Disorders: A Systematic Review Jasielski, Patryk Piędel, Faustyna Piwek, Mikołaj Rocka, Agata Petit, Véronique Rejdak, Konrad Nutrients Review Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhance cognitive functions. In our article, accessible databases were searched for articles regarding citicoline use in neurological diseases. This article has a systemic review form. After rejecting non-eligible reports, 47 remaining articles were reviewed. The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke. In an animal model of nerve damage and neuropathy, citicoline stimulated regeneration and lessened pain. Among patients who underwent brain trauma, citicoline has an unclear clinical effect. Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases. Its positive impact on learning and cognitive functions among the healthy population is also worth noting. MDPI 2020-10-12 /pmc/articles/PMC7601330/ /pubmed/33053828 http://dx.doi.org/10.3390/nu12103113 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jasielski, Patryk
Piędel, Faustyna
Piwek, Mikołaj
Rocka, Agata
Petit, Véronique
Rejdak, Konrad
Application of Citicoline in Neurological Disorders: A Systematic Review
title Application of Citicoline in Neurological Disorders: A Systematic Review
title_full Application of Citicoline in Neurological Disorders: A Systematic Review
title_fullStr Application of Citicoline in Neurological Disorders: A Systematic Review
title_full_unstemmed Application of Citicoline in Neurological Disorders: A Systematic Review
title_short Application of Citicoline in Neurological Disorders: A Systematic Review
title_sort application of citicoline in neurological disorders: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601330/
https://www.ncbi.nlm.nih.gov/pubmed/33053828
http://dx.doi.org/10.3390/nu12103113
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