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Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2

In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with MacTel were imaged with adaptive optics scannin...

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Autores principales: Zandi, Roya, Song, Jessica, Micevych, Paul S., Fawzi, Amani A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601362/
https://www.ncbi.nlm.nih.gov/pubmed/33003381
http://dx.doi.org/10.3390/jcm9103149
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author Zandi, Roya
Song, Jessica
Micevych, Paul S.
Fawzi, Amani A.
author_facet Zandi, Roya
Song, Jessica
Micevych, Paul S.
Fawzi, Amani A.
author_sort Zandi, Roya
collection PubMed
description In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with MacTel were imaged with adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography angiography (OCTA). Confocal AOSLO was used to visualize dark regions of nonwaveguiding outer segments, which we refer to as “photoreceptor lesions”. En-face OCTA images of the deep capillary plexus (DCP) were used in conjunction with confocal AOSLO to evaluate the topographic relationship between areas of capillary telangiectasias and photoreceptor lesions. Among seven eyes with early stage MacTel (stage 0–2 based on OCT), we identified ten photoreceptor lesions, all of which were located within parafoveal quadrants containing DCP telangiectasia on OCTA. Seven of the lesions corresponded to the intact ellipsoid zone on spectral-domain OCT (SD-OCT), and three of these also corresponded to the intact interdigitation zone. This work demonstrates a topographic relationship between AOSLO photoreceptor lesions and DCP telangiectasias, and it also suggests that these lesions with normal SD-OCT appearance may represent areas of photoreceptors at risk for dysfunction. Thus, confocal AOSLO may have a meaningful role in detecting early photoreceptor abnormalities in eyes with MacTel.
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spelling pubmed-76013622020-11-01 Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2 Zandi, Roya Song, Jessica Micevych, Paul S. Fawzi, Amani A. J Clin Med Article In this cross-sectional observational study, we investigated the relationship between photoreceptor layer disruption and telangiectasia in patients diagnosed with early stage macular telangiectasia type 2 (MacTel). A total of 31 eyes (17 patients) with MacTel were imaged with adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography angiography (OCTA). Confocal AOSLO was used to visualize dark regions of nonwaveguiding outer segments, which we refer to as “photoreceptor lesions”. En-face OCTA images of the deep capillary plexus (DCP) were used in conjunction with confocal AOSLO to evaluate the topographic relationship between areas of capillary telangiectasias and photoreceptor lesions. Among seven eyes with early stage MacTel (stage 0–2 based on OCT), we identified ten photoreceptor lesions, all of which were located within parafoveal quadrants containing DCP telangiectasia on OCTA. Seven of the lesions corresponded to the intact ellipsoid zone on spectral-domain OCT (SD-OCT), and three of these also corresponded to the intact interdigitation zone. This work demonstrates a topographic relationship between AOSLO photoreceptor lesions and DCP telangiectasias, and it also suggests that these lesions with normal SD-OCT appearance may represent areas of photoreceptors at risk for dysfunction. Thus, confocal AOSLO may have a meaningful role in detecting early photoreceptor abnormalities in eyes with MacTel. MDPI 2020-09-29 /pmc/articles/PMC7601362/ /pubmed/33003381 http://dx.doi.org/10.3390/jcm9103149 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zandi, Roya
Song, Jessica
Micevych, Paul S.
Fawzi, Amani A.
Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2
title Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2
title_full Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2
title_fullStr Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2
title_full_unstemmed Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2
title_short Topographic Relationship between Telangiectasia and Cone Mosaic Disruption in Macular Telangiectasia Type 2
title_sort topographic relationship between telangiectasia and cone mosaic disruption in macular telangiectasia type 2
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601362/
https://www.ncbi.nlm.nih.gov/pubmed/33003381
http://dx.doi.org/10.3390/jcm9103149
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