Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis

Maturity-onset diabetes of the young (MODY) represents a heterogenous group of monogenic autosomal dominant diseases, which accounts for 1–2% of all diabetes cases. Pregnancy represents a crucial time to diagnose MODY forms due to the 50% risk of inheritance in offspring of affected subjects and the...

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Autores principales: Calcaterra, Valeria, Zanfardino, Angela, Zuccotti, Gian Vincenzo, Iafusco, Dario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601484/
https://www.ncbi.nlm.nih.gov/pubmed/32998381
http://dx.doi.org/10.3390/metabo10100387
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author Calcaterra, Valeria
Zanfardino, Angela
Zuccotti, Gian Vincenzo
Iafusco, Dario
author_facet Calcaterra, Valeria
Zanfardino, Angela
Zuccotti, Gian Vincenzo
Iafusco, Dario
author_sort Calcaterra, Valeria
collection PubMed
description Maturity-onset diabetes of the young (MODY) represents a heterogenous group of monogenic autosomal dominant diseases, which accounts for 1–2% of all diabetes cases. Pregnancy represents a crucial time to diagnose MODY forms due to the 50% risk of inheritance in offspring of affected subjects and the potential implications on adequate fetal weight. Not only a history of maternal diabetes may affect the birth weight of offspring, paternal diabetes should also be taken into consideration for a correct pathogenetic diagnosis. The crucial role of maternal and paternal diabetes inheritance patterns and the impact of this inherited mutation on birthweight and the MODY diagnosis was discussed.
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spelling pubmed-76014842020-11-01 Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis Calcaterra, Valeria Zanfardino, Angela Zuccotti, Gian Vincenzo Iafusco, Dario Metabolites Editorial Maturity-onset diabetes of the young (MODY) represents a heterogenous group of monogenic autosomal dominant diseases, which accounts for 1–2% of all diabetes cases. Pregnancy represents a crucial time to diagnose MODY forms due to the 50% risk of inheritance in offspring of affected subjects and the potential implications on adequate fetal weight. Not only a history of maternal diabetes may affect the birth weight of offspring, paternal diabetes should also be taken into consideration for a correct pathogenetic diagnosis. The crucial role of maternal and paternal diabetes inheritance patterns and the impact of this inherited mutation on birthweight and the MODY diagnosis was discussed. MDPI 2020-09-28 /pmc/articles/PMC7601484/ /pubmed/32998381 http://dx.doi.org/10.3390/metabo10100387 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Calcaterra, Valeria
Zanfardino, Angela
Zuccotti, Gian Vincenzo
Iafusco, Dario
Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis
title Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis
title_full Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis
title_fullStr Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis
title_full_unstemmed Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis
title_short Maternal or Paternal Diabetes and Its Crucial Role in Offspring Birth Weight and MODY Diagnosis
title_sort maternal or paternal diabetes and its crucial role in offspring birth weight and mody diagnosis
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601484/
https://www.ncbi.nlm.nih.gov/pubmed/32998381
http://dx.doi.org/10.3390/metabo10100387
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AT zuccottigianvincenzo maternalorpaternaldiabetesanditscrucialroleinoffspringbirthweightandmodydiagnosis
AT iafuscodario maternalorpaternaldiabetesanditscrucialroleinoffspringbirthweightandmodydiagnosis

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