The Late-Stage Protective Effect of Mito-TEMPO against Acetaminophen-Induced Hepatotoxicity in Mouse and Three-Dimensional Cell Culture Models

An overdose of acetaminophen (APAP), the most common cause of acute liver injury, induces oxidative stress that subsequently causes mitochondrial impairment and hepatic necroptosis. N-acetyl-L-cysteine (NAC), the only recognized drug against APAP hepatotoxicity, is less effective the later it is adm...

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Detalles Bibliográficos
Autores principales: Abdullah-Al-Shoeb, Mohammad, Sasaki, Kenta, Kikutani, Saori, Namba, Nanami, Ueno, Keiichi, Kondo, Yuki, Maeda, Hitoshi, Maruyama, Toru, Irie, Tetsumi, Ishitsuka, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601533/
https://www.ncbi.nlm.nih.gov/pubmed/33050213
http://dx.doi.org/10.3390/antiox9100965

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