Cargando…
The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma
Introduction: Synovial sarcoma (SaSy) is a high-grade, malignant soft tissue sarcoma (STS) accounting for 5–9% of STS. The aim of this study was to analyse outcomes of patients with localised SaSy treated in a single institution with a uniform neo- and adjuvant-combined therapy protocol. Methods: 17...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601566/ https://www.ncbi.nlm.nih.gov/pubmed/32998194 http://dx.doi.org/10.3390/jcm9103129 |
_version_ | 1783603453157703680 |
---|---|
author | Kozak, Katarzyna Teterycz, Paweł Świtaj, Tomasz Koseła-Paterczyk, Hanna Falkowski, Sławomir Morysiński, Tadeusz Bartnik, Ewa Czarnecka, Anna M. Wągrodzki, Michał Ługowska, Iwona Rutkowski, Piotr |
author_facet | Kozak, Katarzyna Teterycz, Paweł Świtaj, Tomasz Koseła-Paterczyk, Hanna Falkowski, Sławomir Morysiński, Tadeusz Bartnik, Ewa Czarnecka, Anna M. Wągrodzki, Michał Ługowska, Iwona Rutkowski, Piotr |
author_sort | Kozak, Katarzyna |
collection | PubMed |
description | Introduction: Synovial sarcoma (SaSy) is a high-grade, malignant soft tissue sarcoma (STS) accounting for 5–9% of STS. The aim of this study was to analyse outcomes of patients with localised SaSy treated in a single institution with a uniform neo- and adjuvant-combined therapy protocol. Methods: 171 patients with stage II/III SaSy were treated between 1997 and 2014. Chemotherapy consisted of 4 cycles of ifosfamide 12 g/m(2) and two cycles of a doxorubicin-based regimen 75 mg/m(2). With the exception of patients who underwent amputation, all patients received neoadjuvant radiotherapy. Results: Median age was 33 years (range 17–69). Tumours larger than 5 cm in size were found in 70% of patients. The 5-year overall survival (OS), local relapse-free survival (LRFS) and metastasis-free survival (MFS) rates were 75%, 80% and 60%, respectively. In multivariate Cox’s regression, age > 35 years, male sex, larger tumour size and histology other than monophasic were associated with worse OS. Conclusions: In adult patients with localised SaSy, long-term survival can be achieved in a significant proportion of cases with intensive combined therapy. The multivariate analysis identified age, sex, disease stage and histology subtype as independent prognostic factors of OS. |
format | Online Article Text |
id | pubmed-7601566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76015662020-11-01 The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma Kozak, Katarzyna Teterycz, Paweł Świtaj, Tomasz Koseła-Paterczyk, Hanna Falkowski, Sławomir Morysiński, Tadeusz Bartnik, Ewa Czarnecka, Anna M. Wągrodzki, Michał Ługowska, Iwona Rutkowski, Piotr J Clin Med Article Introduction: Synovial sarcoma (SaSy) is a high-grade, malignant soft tissue sarcoma (STS) accounting for 5–9% of STS. The aim of this study was to analyse outcomes of patients with localised SaSy treated in a single institution with a uniform neo- and adjuvant-combined therapy protocol. Methods: 171 patients with stage II/III SaSy were treated between 1997 and 2014. Chemotherapy consisted of 4 cycles of ifosfamide 12 g/m(2) and two cycles of a doxorubicin-based regimen 75 mg/m(2). With the exception of patients who underwent amputation, all patients received neoadjuvant radiotherapy. Results: Median age was 33 years (range 17–69). Tumours larger than 5 cm in size were found in 70% of patients. The 5-year overall survival (OS), local relapse-free survival (LRFS) and metastasis-free survival (MFS) rates were 75%, 80% and 60%, respectively. In multivariate Cox’s regression, age > 35 years, male sex, larger tumour size and histology other than monophasic were associated with worse OS. Conclusions: In adult patients with localised SaSy, long-term survival can be achieved in a significant proportion of cases with intensive combined therapy. The multivariate analysis identified age, sex, disease stage and histology subtype as independent prognostic factors of OS. MDPI 2020-09-28 /pmc/articles/PMC7601566/ /pubmed/32998194 http://dx.doi.org/10.3390/jcm9103129 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kozak, Katarzyna Teterycz, Paweł Świtaj, Tomasz Koseła-Paterczyk, Hanna Falkowski, Sławomir Morysiński, Tadeusz Bartnik, Ewa Czarnecka, Anna M. Wągrodzki, Michał Ługowska, Iwona Rutkowski, Piotr The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma |
title | The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma |
title_full | The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma |
title_fullStr | The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma |
title_full_unstemmed | The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma |
title_short | The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma |
title_sort | long-term outcomes of intensive combined therapy of adult patients with localised synovial sarcoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601566/ https://www.ncbi.nlm.nih.gov/pubmed/32998194 http://dx.doi.org/10.3390/jcm9103129 |
work_keys_str_mv | AT kozakkatarzyna thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT teteryczpaweł thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT switajtomasz thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT kosełapaterczykhanna thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT falkowskisławomir thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT morysinskitadeusz thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT bartnikewa thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT czarneckaannam thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT wagrodzkimichał thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT ługowskaiwona thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT rutkowskipiotr thelongtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT kozakkatarzyna longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT teteryczpaweł longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT switajtomasz longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT kosełapaterczykhanna longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT falkowskisławomir longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT morysinskitadeusz longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT bartnikewa longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT czarneckaannam longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT wagrodzkimichał longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT ługowskaiwona longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma AT rutkowskipiotr longtermoutcomesofintensivecombinedtherapyofadultpatientswithlocalisedsynovialsarcoma |