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The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma

Introduction: Synovial sarcoma (SaSy) is a high-grade, malignant soft tissue sarcoma (STS) accounting for 5–9% of STS. The aim of this study was to analyse outcomes of patients with localised SaSy treated in a single institution with a uniform neo- and adjuvant-combined therapy protocol. Methods: 17...

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Autores principales: Kozak, Katarzyna, Teterycz, Paweł, Świtaj, Tomasz, Koseła-Paterczyk, Hanna, Falkowski, Sławomir, Morysiński, Tadeusz, Bartnik, Ewa, Czarnecka, Anna M., Wągrodzki, Michał, Ługowska, Iwona, Rutkowski, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601566/
https://www.ncbi.nlm.nih.gov/pubmed/32998194
http://dx.doi.org/10.3390/jcm9103129
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author Kozak, Katarzyna
Teterycz, Paweł
Świtaj, Tomasz
Koseła-Paterczyk, Hanna
Falkowski, Sławomir
Morysiński, Tadeusz
Bartnik, Ewa
Czarnecka, Anna M.
Wągrodzki, Michał
Ługowska, Iwona
Rutkowski, Piotr
author_facet Kozak, Katarzyna
Teterycz, Paweł
Świtaj, Tomasz
Koseła-Paterczyk, Hanna
Falkowski, Sławomir
Morysiński, Tadeusz
Bartnik, Ewa
Czarnecka, Anna M.
Wągrodzki, Michał
Ługowska, Iwona
Rutkowski, Piotr
author_sort Kozak, Katarzyna
collection PubMed
description Introduction: Synovial sarcoma (SaSy) is a high-grade, malignant soft tissue sarcoma (STS) accounting for 5–9% of STS. The aim of this study was to analyse outcomes of patients with localised SaSy treated in a single institution with a uniform neo- and adjuvant-combined therapy protocol. Methods: 171 patients with stage II/III SaSy were treated between 1997 and 2014. Chemotherapy consisted of 4 cycles of ifosfamide 12 g/m(2) and two cycles of a doxorubicin-based regimen 75 mg/m(2). With the exception of patients who underwent amputation, all patients received neoadjuvant radiotherapy. Results: Median age was 33 years (range 17–69). Tumours larger than 5 cm in size were found in 70% of patients. The 5-year overall survival (OS), local relapse-free survival (LRFS) and metastasis-free survival (MFS) rates were 75%, 80% and 60%, respectively. In multivariate Cox’s regression, age > 35 years, male sex, larger tumour size and histology other than monophasic were associated with worse OS. Conclusions: In adult patients with localised SaSy, long-term survival can be achieved in a significant proportion of cases with intensive combined therapy. The multivariate analysis identified age, sex, disease stage and histology subtype as independent prognostic factors of OS.
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spelling pubmed-76015662020-11-01 The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma Kozak, Katarzyna Teterycz, Paweł Świtaj, Tomasz Koseła-Paterczyk, Hanna Falkowski, Sławomir Morysiński, Tadeusz Bartnik, Ewa Czarnecka, Anna M. Wągrodzki, Michał Ługowska, Iwona Rutkowski, Piotr J Clin Med Article Introduction: Synovial sarcoma (SaSy) is a high-grade, malignant soft tissue sarcoma (STS) accounting for 5–9% of STS. The aim of this study was to analyse outcomes of patients with localised SaSy treated in a single institution with a uniform neo- and adjuvant-combined therapy protocol. Methods: 171 patients with stage II/III SaSy were treated between 1997 and 2014. Chemotherapy consisted of 4 cycles of ifosfamide 12 g/m(2) and two cycles of a doxorubicin-based regimen 75 mg/m(2). With the exception of patients who underwent amputation, all patients received neoadjuvant radiotherapy. Results: Median age was 33 years (range 17–69). Tumours larger than 5 cm in size were found in 70% of patients. The 5-year overall survival (OS), local relapse-free survival (LRFS) and metastasis-free survival (MFS) rates were 75%, 80% and 60%, respectively. In multivariate Cox’s regression, age > 35 years, male sex, larger tumour size and histology other than monophasic were associated with worse OS. Conclusions: In adult patients with localised SaSy, long-term survival can be achieved in a significant proportion of cases with intensive combined therapy. The multivariate analysis identified age, sex, disease stage and histology subtype as independent prognostic factors of OS. MDPI 2020-09-28 /pmc/articles/PMC7601566/ /pubmed/32998194 http://dx.doi.org/10.3390/jcm9103129 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kozak, Katarzyna
Teterycz, Paweł
Świtaj, Tomasz
Koseła-Paterczyk, Hanna
Falkowski, Sławomir
Morysiński, Tadeusz
Bartnik, Ewa
Czarnecka, Anna M.
Wągrodzki, Michał
Ługowska, Iwona
Rutkowski, Piotr
The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma
title The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma
title_full The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma
title_fullStr The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma
title_full_unstemmed The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma
title_short The Long-Term Outcomes of Intensive Combined Therapy of Adult Patients with Localised Synovial Sarcoma
title_sort long-term outcomes of intensive combined therapy of adult patients with localised synovial sarcoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601566/
https://www.ncbi.nlm.nih.gov/pubmed/32998194
http://dx.doi.org/10.3390/jcm9103129
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