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Novel Insights into Molecular Mechanisms of Chronic Pain

Pain is the most frequent cause triggering patients to visit a physician. The worldwide incidence of chronic pain is in the range of 20% of adults, and chronic pain conditions are frequently associated with several comorbidities and a drastic decrease in patients’ quality of life. Although several a...

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Detalles Bibliográficos
Autor principal: Niederberger, Ellen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601569/
https://www.ncbi.nlm.nih.gov/pubmed/33019536
http://dx.doi.org/10.3390/cells9102220
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author Niederberger, Ellen
author_facet Niederberger, Ellen
author_sort Niederberger, Ellen
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description Pain is the most frequent cause triggering patients to visit a physician. The worldwide incidence of chronic pain is in the range of 20% of adults, and chronic pain conditions are frequently associated with several comorbidities and a drastic decrease in patients’ quality of life. Although several approved analgesics are available, such therapy is often not satisfying due to insufficient efficacy and/or severe side effects. Therefore, novel strategies for the development of safe and highly efficacious pain killers are urgently needed. To reach this goal, it is necessary to clarify the causes and signal transduction cascades underlying the onset and progression of the different types of chronic pain. The papers in this Special Issue cover a wide variety of mechanisms involved in different pain types such as inflammatory, neuropathic or cancer pain. Therefore, the results summarized here might contribute to a better understanding of the mechanisms in chronic pain and thereby to the development of novel therapeutic strategies for pain patients.
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spelling pubmed-76015692020-11-01 Novel Insights into Molecular Mechanisms of Chronic Pain Niederberger, Ellen Cells Editorial Pain is the most frequent cause triggering patients to visit a physician. The worldwide incidence of chronic pain is in the range of 20% of adults, and chronic pain conditions are frequently associated with several comorbidities and a drastic decrease in patients’ quality of life. Although several approved analgesics are available, such therapy is often not satisfying due to insufficient efficacy and/or severe side effects. Therefore, novel strategies for the development of safe and highly efficacious pain killers are urgently needed. To reach this goal, it is necessary to clarify the causes and signal transduction cascades underlying the onset and progression of the different types of chronic pain. The papers in this Special Issue cover a wide variety of mechanisms involved in different pain types such as inflammatory, neuropathic or cancer pain. Therefore, the results summarized here might contribute to a better understanding of the mechanisms in chronic pain and thereby to the development of novel therapeutic strategies for pain patients. MDPI 2020-10-01 /pmc/articles/PMC7601569/ /pubmed/33019536 http://dx.doi.org/10.3390/cells9102220 Text en © 2020 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Niederberger, Ellen
Novel Insights into Molecular Mechanisms of Chronic Pain
title Novel Insights into Molecular Mechanisms of Chronic Pain
title_full Novel Insights into Molecular Mechanisms of Chronic Pain
title_fullStr Novel Insights into Molecular Mechanisms of Chronic Pain
title_full_unstemmed Novel Insights into Molecular Mechanisms of Chronic Pain
title_short Novel Insights into Molecular Mechanisms of Chronic Pain
title_sort novel insights into molecular mechanisms of chronic pain
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601569/
https://www.ncbi.nlm.nih.gov/pubmed/33019536
http://dx.doi.org/10.3390/cells9102220
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