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Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential

The genus Streptacidiphilus represents a group of acidophilic actinobacteria within the family Streptomycetaceae, and currently encompasses 15 validly named species, which include five recent additions within the last two years. Considering the potential of the related genera within the family, name...

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Autores principales: Malik, Adeel, Kim, Yu Ri, Kim, Seung Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601586/
https://www.ncbi.nlm.nih.gov/pubmed/33022985
http://dx.doi.org/10.3390/genes11101166
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author Malik, Adeel
Kim, Yu Ri
Kim, Seung Bum
author_facet Malik, Adeel
Kim, Yu Ri
Kim, Seung Bum
author_sort Malik, Adeel
collection PubMed
description The genus Streptacidiphilus represents a group of acidophilic actinobacteria within the family Streptomycetaceae, and currently encompasses 15 validly named species, which include five recent additions within the last two years. Considering the potential of the related genera within the family, namely Streptomyces and Kitasatospora, these relatively new members of the family can also be a promising source for novel secondary metabolites. At present, 15 genome data for 11 species from this genus are available, which can provide valuable information on their biology including the potential for metabolite production as well as enzymatic activities in comparison to the neighboring taxa. In this study, the genome sequences of 11 Streptacidiphilus species were subjected to the comparative analysis together with selected Streptomyces and Kitasatospora genomes. This study represents the first comprehensive comparative genomic analysis of the genus Streptacidiphilus. The results indicate that the genomes of Streptacidiphilus contained various secondary metabolite (SM) producing biosynthetic gene clusters (BGCs), some of them exclusively identified in Streptacidiphilus only. Several of these clusters may potentially code for SMs that may have a broad range of bioactivities, such as antibacterial, antifungal, antimalarial and antitumor activities. The biodegradation capabilities of Streptacidiphilus were also explored by investigating the hydrolytic enzymes for complex carbohydrates. Although all genomes were enriched with carbohydrate-active enzymes (CAZymes), their numbers in the genomes of some strains such as Streptacidiphilus carbonis NBRC 100919(T) were higher as compared to well-known carbohydrate degrading organisms. These distinctive features of each Streptacidiphilus species make them interesting candidates for future studies with respect to their potential for SM production and enzymatic activities.
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spelling pubmed-76015862020-11-01 Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential Malik, Adeel Kim, Yu Ri Kim, Seung Bum Genes (Basel) Article The genus Streptacidiphilus represents a group of acidophilic actinobacteria within the family Streptomycetaceae, and currently encompasses 15 validly named species, which include five recent additions within the last two years. Considering the potential of the related genera within the family, namely Streptomyces and Kitasatospora, these relatively new members of the family can also be a promising source for novel secondary metabolites. At present, 15 genome data for 11 species from this genus are available, which can provide valuable information on their biology including the potential for metabolite production as well as enzymatic activities in comparison to the neighboring taxa. In this study, the genome sequences of 11 Streptacidiphilus species were subjected to the comparative analysis together with selected Streptomyces and Kitasatospora genomes. This study represents the first comprehensive comparative genomic analysis of the genus Streptacidiphilus. The results indicate that the genomes of Streptacidiphilus contained various secondary metabolite (SM) producing biosynthetic gene clusters (BGCs), some of them exclusively identified in Streptacidiphilus only. Several of these clusters may potentially code for SMs that may have a broad range of bioactivities, such as antibacterial, antifungal, antimalarial and antitumor activities. The biodegradation capabilities of Streptacidiphilus were also explored by investigating the hydrolytic enzymes for complex carbohydrates. Although all genomes were enriched with carbohydrate-active enzymes (CAZymes), their numbers in the genomes of some strains such as Streptacidiphilus carbonis NBRC 100919(T) were higher as compared to well-known carbohydrate degrading organisms. These distinctive features of each Streptacidiphilus species make them interesting candidates for future studies with respect to their potential for SM production and enzymatic activities. MDPI 2020-10-03 /pmc/articles/PMC7601586/ /pubmed/33022985 http://dx.doi.org/10.3390/genes11101166 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Malik, Adeel
Kim, Yu Ri
Kim, Seung Bum
Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential
title Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential
title_full Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential
title_fullStr Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential
title_full_unstemmed Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential
title_short Genome Mining of the Genus Streptacidiphilus for Biosynthetic and Biodegradation Potential
title_sort genome mining of the genus streptacidiphilus for biosynthetic and biodegradation potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7601586/
https://www.ncbi.nlm.nih.gov/pubmed/33022985
http://dx.doi.org/10.3390/genes11101166
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